1287761-01-6

1287761-01-6 structure

Name: PTUPB
Chemical Name: 4-{5-Phenyl-3-[3-({[4-(trifluoromethyl)phenyl]carbamoyl}amino)propyl]-1H-pyrazol-1-yl}benzenesulfonamide
CAS Number: 1287761-01-6
Molecular Formula: C₂₆H₂₄F₃N₅O₃S
Molecular Weight: 543.561
Catalog: Signaling Pathways Immunology/Inflammation COX
Create Date: 2020-01-11 18:28:50
Modify Date: 2024-01-13 23:50:13
PTUPB is a novel dual acting COX-2/sEH inhibitor with IC50 of 1.26 uM/0.9 nM,does not inhibits COX-1 (IC50>100 uM); reduces kidney injury parameters, decreases inflammatory and oxidative stress markers in ZDF rats; exhibits more effective than the same dose of either COX-2 inhibitor (celecoxib) or sEH inhibitor (t-AUCB) alone, shows in vivo antiallodynic activity in vivo; also suppresses glioblastoma growth by targeting EGFR and hyaluronan mediated motility receptor, potentiates the antitumor efficacy of cisplatin.

Name	4-{5-Phenyl-3-[3-({[4-(trifluoromethyl)phenyl]carbamoyl}amino)propyl]-1H-pyrazol-1-yl}benzenesulfonamide
Synonyms	4-{5-Phenyl-3-[3-({[4-(trifluoromethyl)phenyl]carbamoyl}amino)propyl]-1H-pyrazol-1-yl}benzenesulfonamide Benzenesulfonamide, 4-[5-phenyl-3-[3-[[[[4-(trifluoromethyl)phenyl]amino]carbonyl]amino]propyl]-1H-pyrazol-1-yl]-

Description	PTUPB is a novel dual acting COX-2/sEH inhibitor with IC50 of 1.26 uM/0.9 nM,does not inhibits COX-1 (IC50>100 uM); reduces kidney injury parameters, decreases inflammatory and oxidative stress markers in ZDF rats; exhibits more effective than the same dose of either COX-2 inhibitor (celecoxib) or sEH inhibitor (t-AUCB) alone, shows in vivo antiallodynic activity in vivo; also suppresses glioblastoma growth by targeting EGFR and hyaluronan mediated motility receptor, potentiates the antitumor efficacy of cisplatin.
References	References 1. Hye Khan MA, et al. Prostaglandins Other Lipid Mediat. 2016 Sep;125:40-7. 2. Li J, et al. Oncotarget. 2017 Sep 15;8(50):87353-87363. 3. Wang F, et al. Mol Cancer Ther. 2018 Feb;17(2):474-483. 4. Hwang SH, et al. J Med Chem. 2011 Apr 28;54(8):3037-50. View Related Products by Target Cyclooxygenase (COX)