PTUPB

Names

[ Name ]:
PTUPB

[Synonym ]:
4-{5-Phenyl-3-[3-({[4-(trifluoromethyl)phenyl]carbamoyl}amino)propyl]-1H-pyrazol-1-yl}benzenesulfonamide
Benzenesulfonamide, 4-[5-phenyl-3-[3-[[[[4-(trifluoromethyl)phenyl]amino]carbonyl]amino]propyl]-1H-pyrazol-1-yl]-

Biological Activity

[Description]:

PTUPB is a novel dual acting COX-2/sEH inhibitor with IC50 of 1.26 uM/0.9 nM,does not inhibits COX-1 (IC50>100 uM); reduces kidney injury parameters, decreases inflammatory and oxidative stress markers in ZDF rats; exhibits more effective than the same dose of either COX-2 inhibitor (celecoxib) or sEH inhibitor (t-AUCB) alone, shows in vivo antiallodynic activity in vivo; also suppresses glioblastoma growth by targeting EGFR and hyaluronan mediated motility receptor, potentiates the antitumor efficacy of cisplatin.

[References]

References 1. Hye Khan MA, et al. Prostaglandins Other Lipid Mediat. 2016 Sep;125:40-7. 2. Li J, et al. Oncotarget. 2017 Sep 15;8(50):87353-87363. 3. Wang F, et al. Mol Cancer Ther. 2018 Feb;17(2):474-483. 4. Hwang SH, et al. J Med Chem. 2011 Apr 28;54(8):3037-50. View Related Products by Target Cyclooxygenase (COX)

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C₂₆H₂₄F₃N₅O₃S

[ Molecular Weight ]:
543.561

[ Exact Mass ]:
543.155212

[ LogP ]:
4.91

[ Index of Refraction ]:
1.626

Related Compounds

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