VU0529331

Modify Date: 2024-01-15 14:19:49

VU0529331 Structure
VU0529331 structure
Common Name VU0529331
CAS Number 1286725-49-2 Molecular Weight 384.43
Density N/A Boiling Point N/A
Molecular Formula C22H20N6O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of VU0529331


VU0529331 is a modestly selective non-GIRK1-containing G protein-gated, inwardly-rectifying, potassium channel (non-GIRK1/X) activator, with EC50s of 5.1 µM and 5.2 µM for GIRK2 and GIRK1/2 in HEK293 cells, respectively, also effective on GIRK4 homomeric channel[1].

 Names

Name VU0529331

 VU0529331 Biological Activity

Description VU0529331 is a modestly selective non-GIRK1-containing G protein-gated, inwardly-rectifying, potassium channel (non-GIRK1/X) activator, with EC50s of 5.1 µM and 5.2 µM for GIRK2 and GIRK1/2 in HEK293 cells, respectively, also effective on GIRK4 homomeric channel[1].
Related Catalog
Target

EC50: 5.1 µM (GIRK2), 5.2 µM (GIRK1/2)[1]

References

[1]. Kozek KA, et al. Discovery and Characterization of VU0529331, a Synthetic Small-Molecule Activator of Homomeric G Protein-Gated, Inwardly Rectifying, Potassium (GIRK) Channels. ACS Chem Neurosci. 2018 Sep 13.

 Chemical & Physical Properties

Molecular Formula C22H20N6O
Molecular Weight 384.43
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