VU0529331

Names

[ Name ]:
VU0529331

Biological Activity

[Description]:

VU0529331 is a modestly selective non-GIRK1-containing G protein-gated, inwardly-rectifying, potassium channel (non-GIRK1/X) activator, with EC50s of 5.1 µM and 5.2 µM for GIRK2 and GIRK1/2 in HEK293 cells, respectively, also effective on GIRK4 homomeric channel[1].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[Target]

EC50: 5.1 µM (GIRK2), 5.2 µM (GIRK1/2)[1]

[References]

[1]. Kozek KA, et al. Discovery and Characterization of VU0529331, a Synthetic Small-Molecule Activator of Homomeric G Protein-Gated, Inwardly Rectifying, Potassium (GIRK) Channels. ACS Chem Neurosci. 2018 Sep 13.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₂₀N₆O

[ Molecular Weight ]:
384.43

Related Compounds

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