VP3.15

Modify Date: 2024-01-11 19:49:49

VP3.15 structure	Common Name	VP3.15
	CAS Number	1281681-54-6	Molecular Weight	366.48
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₀H₂₂N₄OS	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of VP3.15

VP3.15 is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. VP3.15 has neuroprotective and neuroreparative activities, thus as potential combined anti-inflammatory and pro-remyelinating therapies for multiple sclerosis (MS)[1].

Name	VP3.15

Description	VP3.15 is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. VP3.15 has neuroprotective and neuroreparative activities, thus as potential combined anti-inflammatory and pro-remyelinating therapies for multiple sclerosis (MS)[1].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> GSK-3 Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Research Areas >> Neurological Disease Signaling Pathways >> PI3K/Akt/mTOR >> GSK-3
Target	IC50: 1.59 μM (PDE7), 0.88 μM (GSK-3)[1]
References	[1]. Medina-Rodríguez EM, et al. Promoting in vivo remyelination with small molecules: a neuroreparative pharmacological treatment for Multiple Sclerosis. Sci Rep. 2017 Mar 3;7:43545.

Molecular Formula	C₂₀H₂₂N₄OS
Molecular Weight	366.48

VP3.15

Use of VP3.15

Names

VP3.15 Biological Activity

Chemical & Physical Properties