Benazepril-d5 (hydrochloride)

Modify Date: 2024-01-12 15:00:41

Benazepril-d5 (hydrochloride) structure	Common Name	Benazepril-d5 (hydrochloride)
	CAS Number	1279026-26-4	Molecular Weight	465.98
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₄H₂₄D₅ClN₂O₅	Melting Point	178-180°C
	MSDS	N/A	Flash Point	N/A

Use of Benazepril-d5 (hydrochloride)

Benazepril-d5 (hydrochloride) is deuterium labeled Benazepril (hydrochloride).

Name	[(3S)-3-{[(2S)-1-Ethoxy-1-oxo-4-(2H5)phenyl-2-butanyl]amino}-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]acetic acid hydrochloride (1:1)
Synonym	More Synonyms

Description	Benazepril-d5 (hydrochloride) is deuterium labeled Benazepril (hydrochloride).
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE)
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Hou FF, et al. Efficacy and safety of benazepril for advanced chronic renal insufficiency. N Engl J Med. 2006 Jan 12;354(2):131-40. [3]. Huang XM, et al. Effects of chronotherapy of benazepril on the diurnal profile of RAAS and clock genes in the kidney of 5/6 nephrectomy rats. J Huazhong Univ Sci Technolog Med Sci. 2013 Jun;33(3):368-74.

[(3S)-3-{[(2S)-1-Ethoxy-1-oxo-4-(2H5)phenyl-2-butanyl]amino}-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]acetic acid hydrochloride (1:1)

1H-1-Benzazepine-1-acetic acid, 3-[[(1S)-1-(ethoxycarbonyl)-3-(phenyl-d5)propyl]amino]-2,3,4,5-tetrahydro-2-oxo-, (3S)-, hydrochloride (1:1)

Get all suppliers and price by the below link: