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Benazepril-d5 (hydrochloride)

Names

[ CAS No. ]:
1279026-26-4

[ Name ]:
Benazepril-d5 (hydrochloride)

[Synonym ]:
[(3S)-3-{[(2S)-1-Ethoxy-1-oxo-4-(2H5)phenyl-2-butanyl]amino}-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]acetic acid hydrochloride (1:1)
1H-1-Benzazepine-1-acetic acid, 3-[[(1S)-1-(ethoxycarbonyl)-3-(phenyl-d5)propyl]amino]-2,3,4,5-tetrahydro-2-oxo-, (3S)-, hydrochloride (1:1)

Biological Activity

[Description]:

Benazepril-d5 (hydrochloride) is deuterium labeled Benazepril (hydrochloride).

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE)

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Hou FF, et al. Efficacy and safety of benazepril for advanced chronic renal insufficiency. N Engl J Med. 2006 Jan 12;354(2):131-40.

[3]. Huang XM, et al. Effects of chronotherapy of benazepril on the diurnal profile of RAAS and clock genes in the kidney of 5/6 nephrectomy rats. J Huazhong Univ Sci Technolog Med Sci. 2013 Jun;33(3):368-74.

Chemical & Physical Properties

[ Melting Point ]:
178-180°C

[ Molecular Formula ]:
C24H24D5ClN2O5

[ Molecular Weight ]:
465.98

[ Exact Mass ]:
465.207886

[ Storage condition ]:
-20C

Related Compounds