cyclic-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine
Modify Date: 2025-08-24 00:00:05
cyclic-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine structure
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Common Name | cyclic-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine | ||
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| CAS Number | 127757-45-3 | Molecular Weight | 261.17200 | |
| Density | 1.83g/cm3 | Boiling Point | 495.6ºC at 760mmHg | |
| Molecular Formula | C8H12N3O5P | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 253.5ºC | |
Use of cyclic-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosineCyclic HPMPC is a potent antiviral agent. Cyclic HPMPC can increase arterial oxygen saturation levels in lethal vaccinia virus (IHD strain)-infected mice. Cyclic HPMPC improves the outcome of congenital guinea pig cytomegalovirus (GPCMV) infection and decreases viral replication in guinea pig model[1][2]. |
| Name | 4-amino-1-[[(5S)-2-hydroxy-2-oxo-1,4,2λ5-dioxaphosphinan-5-yl]methyl]pyrimidin-2-one |
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| Synonym | More Synonyms |
| Description | Cyclic HPMPC is a potent antiviral agent. Cyclic HPMPC can increase arterial oxygen saturation levels in lethal vaccinia virus (IHD strain)-infected mice. Cyclic HPMPC improves the outcome of congenital guinea pig cytomegalovirus (GPCMV) infection and decreases viral replication in guinea pig model[1][2]. |
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| Related Catalog | |
| Target |
Vaccinia virus, GPCMV[1] |
| Density | 1.83g/cm3 |
|---|---|
| Boiling Point | 495.6ºC at 760mmHg |
| Molecular Formula | C8H12N3O5P |
| Molecular Weight | 261.17200 |
| Flash Point | 253.5ºC |
| Exact Mass | 261.05100 |
| PSA | 127.47000 |
| Vapour Pressure | 3.57E-11mmHg at 25°C |
| Index of Refraction | 1.709 |
| InChIKey | YXQUGSXUDFTPLL-LURJTMIESA-N |
| SMILES | Nc1ccn(CC2COP(=O)(O)CO2)c(=O)n1 |
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cyclic-1-(3-hyd... CAS#:127757-45-3 |
| Literature: Beadle, James R.; Hartline, Caroll; Aldern, Kathy A.; Rodriguez, Natalie; Harden, Emma; Kern, Earl R.; Hostetler, Karl Y. Antimicrobial Agents and Chemotherapy, 2002 , vol. 46, # 8 p. 2381 - 2386 |
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cyclic-1-(3-hyd... CAS#:127757-45-3 |
| Literature: Holy, Antonin; Rosenberg, Ivan; Dvorakova, Hana Collection of Czechoslovak Chemical Communications, 1989 , vol. 54, # 9 p. 2470 - 2501 |
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cyclic-1-(3-hyd... CAS#:127757-45-3 |
| Literature: Holy, Antonin; Rosenberg, Ivan; Dvorakova, Hana Collection of Czechoslovak Chemical Communications, 1989 , vol. 54, # 9 p. 2470 - 2501 |
| Precursor 2 | |
|---|---|
| DownStream 0 | |
| cyclic cidofovir |
| cCDV |
| cyclic HPMPC |
| Chpmpc |
| GS 930 |