127757-45-3
127757-45-3 structure
- Name: cyclic-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine
- Chemical Name: 4-amino-1-[[(5S)-2-hydroxy-2-oxo-1,4,2λ5-dioxaphosphinan-5-yl]methyl]pyrimidin-2-one
- CAS Number: 127757-45-3
- Molecular Formula: C8H12N3O5P
- Molecular Weight: 261.17200
- Catalog: Signaling Pathways Anti-infection CMV
- Create Date: 2018-06-21 23:15:47
- Modify Date: 2025-08-24 00:00:05
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Cyclic HPMPC is a potent antiviral agent. Cyclic HPMPC can increase arterial oxygen saturation levels in lethal vaccinia virus (IHD strain)-infected mice. Cyclic HPMPC improves the outcome of congenital guinea pig cytomegalovirus (GPCMV) infection and decreases viral replication in guinea pig model[1][2].
| Name | 4-amino-1-[[(5S)-2-hydroxy-2-oxo-1,4,2λ5-dioxaphosphinan-5-yl]methyl]pyrimidin-2-one |
|---|---|
| Synonyms |
cyclic cidofovir
cCDV cyclic HPMPC Chpmpc GS 930 |
| Description | Cyclic HPMPC is a potent antiviral agent. Cyclic HPMPC can increase arterial oxygen saturation levels in lethal vaccinia virus (IHD strain)-infected mice. Cyclic HPMPC improves the outcome of congenital guinea pig cytomegalovirus (GPCMV) infection and decreases viral replication in guinea pig model[1][2]. |
|---|---|
| Related Catalog | |
| Target |
Vaccinia virus, GPCMV[1] |
| Density | 1.83g/cm3 |
|---|---|
| Boiling Point | 495.6ºC at 760mmHg |
| Molecular Formula | C8H12N3O5P |
| Molecular Weight | 261.17200 |
| Flash Point | 253.5ºC |
| Exact Mass | 261.05100 |
| PSA | 127.47000 |
| Vapour Pressure | 3.57E-11mmHg at 25°C |
| Index of Refraction | 1.709 |
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127757-45-3 |
| Literature: Beadle, James R.; Hartline, Caroll; Aldern, Kathy A.; Rodriguez, Natalie; Harden, Emma; Kern, Earl R.; Hostetler, Karl Y. Antimicrobial Agents and Chemotherapy, 2002 , vol. 46, # 8 p. 2381 - 2386 |
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127757-45-3 |
| Literature: Holy, Antonin; Rosenberg, Ivan; Dvorakova, Hana Collection of Czechoslovak Chemical Communications, 1989 , vol. 54, # 9 p. 2470 - 2501 |
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127757-45-3 |
| Literature: Holy, Antonin; Rosenberg, Ivan; Dvorakova, Hana Collection of Czechoslovak Chemical Communications, 1989 , vol. 54, # 9 p. 2470 - 2501 |
| Precursor 2 | |
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| DownStream 0 | |