cyclic-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine

Names

[ Name ]:
cyclic-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine

[Synonym ]:
cyclic cidofovir
cCDV
cyclic HPMPC
Chpmpc
GS 930

Biological Activity

[Description]:

Cyclic HPMPC is a potent antiviral agent. Cyclic HPMPC can increase arterial oxygen saturation levels in lethal vaccinia virus (IHD strain)-infected mice. Cyclic HPMPC improves the outcome of congenital guinea pig cytomegalovirus (GPCMV) infection and decreases viral replication in guinea pig model[1][2].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> CMV

[Target]

Vaccinia virus, GPCMV[1]

Chemical & Physical Properties

[ Density]:
1.83g/cm3

[ Boiling Point ]:
495.6ºC at 760mmHg

[ Molecular Formula ]:
C₈H₁₂N₃O₅P

[ Molecular Weight ]:
261.17200

[ Flash Point ]:
253.5ºC

[ Exact Mass ]:
261.05100

[ PSA ]:
127.47000

[ Vapour Pressure ]:
3.57E-11mmHg at 25°C

[ Index of Refraction ]:
1.709

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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