N-(4-Ethoxyphenylcarbonyl)-1,1,4,4-tetramethyltetralin-6-carboxamide

Modify Date: 2024-01-15 09:18:44

N-(4-Ethoxyphenylcarbonyl)-1,1,4,4-tetramethyltetralin-6-carboxamide Structure
N-(4-Ethoxyphenylcarbonyl)-1,1,4,4-tetramethyltetralin-6-carboxamide structure
Common Name N-(4-Ethoxyphenylcarbonyl)-1,1,4,4-tetramethyltetralin-6-carboxamide
CAS Number 127697-58-9 Molecular Weight 379.49200
Density 1.095g/cm3 Boiling Point 457.4ºC at 760 mmHg
Molecular Formula C24H29NO3 Melting Point N/A
MSDS N/A Flash Point 230.5ºC

 Use of N-(4-Ethoxyphenylcarbonyl)-1,1,4,4-tetramethyltetralin-6-carboxamide


SRI 6409-94 is an orally active Ro 13-6298 analogue that is teratogenic. SRI 6409-94 serves as a molecular tool to study the effect of the three-dimensional configuration of retinol on teratogenic activity[1][2].

 Names

Name ethyl 4-[(5,5,8,8-tetramethyl-6,7-dihydronaphthalene-2-carbonyl)amino]benzoate
Synonym More Synonyms

  Biological Activity

Description SRI 6409-94 is an orally active Ro 13-6298 analogue that is teratogenic. SRI 6409-94 serves as a molecular tool to study the effect of the three-dimensional configuration of retinol on teratogenic activity[1][2].
Related Catalog
In Vivo SRI 6409-94 causes virgin female outbred syrian golden hamciasters to produce deformed offspring, in a dose-dependent manner[1]. SRI 6409-94 leads to reductions in mean fetal body weight and in the numbers of ossified skeletal districts, significantly[1].
References

[1]. Willhite CC, et al. Structure-activity relationships of retinoids in developmental toxicology. IV. Planar Cisoid conformational restriction. Toxicol Appl Pharmacol. 1990 Apr;103(2):324-44.  

[2]. Willhite CC, et al. Structure-affinity relationships of retinoids with embryonic cellular retinoic acid-binding protein. Toxicol Appl Pharmacol. 1992 Jan;112(1):144-53.  

 Chemical & Physical Properties

Density 1.095g/cm3
Boiling Point 457.4ºC at 760 mmHg
Molecular Formula C24H29NO3
Molecular Weight 379.49200
Flash Point 230.5ºC
Exact Mass 379.21500
PSA 55.40000
LogP 5.53760
Vapour Pressure 1.49E-08mmHg at 25°C
Index of Refraction 1.564

 Synonyms

sri 6409-94
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