N-(4-Ethoxyphenylcarbonyl)-1,1,4,4-tetramethyltetralin-6-carboxamide

Names

[ Name ]:
N-(4-Ethoxyphenylcarbonyl)-1,1,4,4-tetramethyltetralin-6-carboxamide

[Synonym ]:
sri 6409-94

Biological Activity

[Description]:

SRI 6409-94 is an orally active Ro 13-6298 analogue that is teratogenic. SRI 6409-94 serves as a molecular tool to study the effect of the three-dimensional configuration of retinol on teratogenic activity[1][2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vivo]

SRI 6409-94 causes virgin female outbred syrian golden hamciasters to produce deformed offspring, in a dose-dependent manner[1]. SRI 6409-94 leads to reductions in mean fetal body weight and in the numbers of ossified skeletal districts, significantly[1].

[References]

[1]. Willhite CC, et al. Structure-activity relationships of retinoids in developmental toxicology. IV. Planar Cisoid conformational restriction. Toxicol Appl Pharmacol. 1990 Apr;103(2):324-44.

[2]. Willhite CC, et al. Structure-affinity relationships of retinoids with embryonic cellular retinoic acid-binding protein. Toxicol Appl Pharmacol. 1992 Jan;112(1):144-53.

Chemical & Physical Properties

[ Density]:
1.095g/cm3

[ Boiling Point ]:
457.4ºC at 760 mmHg

[ Molecular Formula ]:
C₂₄H₂₉NO₃

[ Molecular Weight ]:
379.49200

[ Flash Point ]:
230.5ºC

[ Exact Mass ]:
379.21500

[ PSA ]:
55.40000

[ LogP ]:
5.53760

[ Vapour Pressure ]:
1.49E-08mmHg at 25°C

[ Index of Refraction ]:
1.564

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.