Spadin

Modify Date: 2024-01-12 11:59:36

Spadin Structure
Spadin structure
Common Name Spadin
CAS Number 1270083-24-3 Molecular Weight 2012.34
Density N/A Boiling Point N/A
Molecular Formula C96H142N26O22 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Spadin


Spadin, a natural peptide derived from a propeptide released in blood, is able to block the TREK-1 (KCNK2 or K2P2.1) channel activity. Spadin binds specifically to TREK-1 with an affinity of 10 nM. Spadin is an efficient antidepressant in mice[1].

 Names

Name Spadin

 Spadin Biological Activity

Description Spadin, a natural peptide derived from a propeptide released in blood, is able to block the TREK-1 (KCNK2 or K2P2.1) channel activity. Spadin binds specifically to TREK-1 with an affinity of 10 nM. Spadin is an efficient antidepressant in mice[1].
Related Catalog
References

[1]. Jean Mazella, et al. Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design. PLoS Biol. 2010 Apr 13;8(4):e1000355.

 Chemical & Physical Properties

Molecular Formula C96H142N26O22
Molecular Weight 2012.34
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