1270083-24-3

1270083-24-3 structure

Name: Spadin
Chemical Name: Spadin
CAS Number: 1270083-24-3
Molecular Formula: C₉₆H₁₄₂N₂₆O₂₂
Molecular Weight: 2012.34
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Potassium Channel
Create Date: 2021-01-12 19:18:53
Modify Date: 2024-01-12 11:59:36
Spadin, a natural peptide derived from a propeptide released in blood, is able to block the TREK-1 (KCNK2 or K2P2.1) channel activity. Spadin binds specifically to TREK-1 with an affinity of 10 nM. Spadin is an efficient antidepressant in mice[1].

Name	Spadin

Description	Spadin, a natural peptide derived from a propeptide released in blood, is able to block the TREK-1 (KCNK2 or K2P2.1) channel activity. Spadin binds specifically to TREK-1 with an affinity of 10 nM. Spadin is an efficient antidepressant in mice[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
References	[1]. Jean Mazella, et al. Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design. PLoS Biol. 2010 Apr 13;8(4):e1000355.

Molecular Formula	C₉₆H₁₄₂N₂₆O₂₂
Molecular Weight	2012.34