NB-360
Modify Date: 2025-08-25 20:46:06
NB-360 structure
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Common Name | NB-360 | ||
|---|---|---|---|---|
| CAS Number | 1262857-73-7 | Molecular Weight | 449.40 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H19F4N5O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of NB-360NB-360 is a potent, brain penetrable, and orally bioavailable dual BACE1/BACE2 inhibitor (IC50: mouse and human BACE1=5 nM; BACE2=6 nM). NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in amyloid precursor protein(APP) transgenic mice. NB-360 can completely block the progression of Aβ deposition in the brains of APP transgenic mice. NB-360 shows excellent selectivity over the related aspartyl proteases pepsin, cathepsin D and cathepsin E[1][2]. |
| Name | NB-360 |
|---|
| Description | NB-360 is a potent, brain penetrable, and orally bioavailable dual BACE1/BACE2 inhibitor (IC50: mouse and human BACE1=5 nM; BACE2=6 nM). NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in amyloid precursor protein(APP) transgenic mice. NB-360 can completely block the progression of Aβ deposition in the brains of APP transgenic mice. NB-360 shows excellent selectivity over the related aspartyl proteases pepsin, cathepsin D and cathepsin E[1][2]. |
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| Related Catalog | |
| Target |
IC50: 5 nM (Mouse and human BACE1), 6 nM (BACE2)[1] |
| References |
[1]. Neumann U, et al. Mol Neurodegener. 2015 Sep 3;10:44. doi: 10.1186/s13024-015-0033-8. |
| Molecular Formula | C21H19F4N5O2 |
|---|---|
| Molecular Weight | 449.40 |
| InChIKey | BQFHTVUWPJXLOW-VQTJNVASSA-N |
| SMILES | Cc1cc(C#N)cnc1C(=O)Nc1ccc(F)c(C2(C)COC(C)(C(F)(F)F)C(N)=N2)c1 |