NB-360
Names
[ CAS No. ]:
1262857-73-7
[ Name ]:
NB-360
Biological Activity
[Description]:
NB-360 is a potent, brain penetrable, and orally bioavailable dual BACE1/BACE2 inhibitor (IC50: mouse and human BACE1=5 nM; BACE2=6 nM). NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in amyloid precursor protein(APP) transgenic mice. NB-360 can completely block the progression of Aβ deposition in the brains of APP transgenic mice. NB-360 shows excellent selectivity over the related aspartyl proteases pepsin, cathepsin D and cathepsin E[1][2].
[Related Catalog]:
[Target]
IC50: 5 nM (Mouse and human BACE1), 6 nM (BACE2)[1]
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C21H19F4N5O2
[ Molecular Weight ]:
449.40