PF-956980
Modify Date: 2025-08-25 11:27:31
PF-956980 structure
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Common Name | PF-956980 | ||
|---|---|---|---|---|
| CAS Number | 1262832-74-5 | Molecular Weight | 342.439 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C18H26N6O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PF-956980PF-00956980 is a reversible pan-JAK inhibitor with IC50 values of 2.2, 23.1 and 59.9 μM for JAK1, JAK2 and JAK3, respectively. PF-00956980 can be used in the research of lung and skin inflammatory diseases[1]. |
| Name | PF-956980 |
|---|---|
| Synonym | More Synonyms |
| Description | PF-00956980 is a reversible pan-JAK inhibitor with IC50 values of 2.2, 23.1 and 59.9 μM for JAK1, JAK2 and JAK3, respectively. PF-00956980 can be used in the research of lung and skin inflammatory diseases[1]. |
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| Related Catalog | |
| Target |
JAK1:2.2 μM (IC50) JAK2:23.1 μM (IC50) JAK3:59.9 μM (IC50) |
| In Vivo | The pharmacokinetic parameters of PF-00956980(compound 2) in rat or dog Spesies Dose (mg/kg) Cl (mL/min/Kg) Clunbound (mL/min/Kg) Vss (L/Kg) Terminal T1/2 (h) Oral Bioavailability Rat i.v. 0.5 48 >48,000 0.8 2.1 - Rat p.o. 1 - - - - <5% Dog i.v. 0.1 18 >18,000 1.0 2.0 - |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Molecular Formula | C18H26N6O |
| Molecular Weight | 342.439 |
| Exact Mass | 342.216797 |
| LogP | 2.35 |
| Index of Refraction | 1.658 |
| Storage condition | Store at -20°C |
| ((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)(pyrrolidin-1-yl)methanone |
| Methanone, [(3R,4R)-4-methyl-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1-piperidinyl]-1-pyrrolidinyl- |
| {(3R,4R)-4-Methyl-3-[methyl(1H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-1-piperidinyl}(1-pyrrolidinyl)methanone |