Amiodarone-d10 hydrochloride

Modify Date: 2024-01-12 18:35:09

Amiodarone-d10 hydrochloride structure	Common Name	Amiodarone-d10 hydrochloride
	CAS Number	1261393-77-4	Molecular Weight	691.83
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₅H₂₀D₁₀ClI₂NO₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Amiodarone-d10 hydrochloride

Amiodarone-d10 hydrochloride is the deuterium labeled Amiodarone. Amiodarone hydrochloride is an antiarrhythmic drug for inhibition of ATP-sensitive potassium channel with an IC50 of 19.1 μM[1][2].

Name	Amiodarone-d10 hydrochloride

Description	Amiodarone-d10 hydrochloride is the deuterium labeled Amiodarone. Amiodarone hydrochloride is an antiarrhythmic drug for inhibition of ATP-sensitive potassium channel with an IC50 of 19.1 μM[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Singh, B.N. and E.M. Vaughan Williams, The effect of amiodarone, a new anti-anginal drug, on cardiac muscle. Br J Pharmacol, 1970. 39(4): p. 657-67. [3]. Rosenbaum, M.B., et al., Clinical efficacy of amiodarone as an antiarrhythmic agent. Am J Cardiol, 1976. 38(7): p. 934-44.

Molecular Formula	C₂₅H₂₀D₁₀ClI₂NO₃
Molecular Weight	691.83
Storage condition	2-8°C