Sarsasapogenin

Modify Date: 2024-01-03 11:14:13

Sarsasapogenin Structure
Sarsasapogenin structure
 Common Name Sarsasapogenin
CAS Number 126-19-2 Molecular Weight 416.637
Density 1.1±0.1 g/cm3 Boiling Point 516.6±20.0 °C at 760 mmHg
Molecular Formula C27H44O3 Melting Point 194°C
MSDS Chinese USA Flash Point 266.2±21.8 °C

 Use of Sarsasapogenin


Sarsasapogenin is a sapogenin from the Chinese medical herb Anemarrhena asphodeloides Bunge, with antidiabetic, anti-oxidative, anticancer and anti-inflamatory activities.

 Names

Name (25S)-5β-spirostan-3β-ol
Synonym More Synonyms

 Sarsasapogenin Biological Activity

Description Sarsasapogenin is a sapogenin from the Chinese medical herb Anemarrhena asphodeloides Bunge, with antidiabetic, anti-oxidative, anticancer and anti-inflamatory activities.
Related Catalog
Target

NF-κB
In Vitro Sarsasapogenin (20-80 μM) induces apoptosis via caspase-dependent mitochondrial pathway in heLa cells. Sarsasapogenin also induces apoptosis via the caspase-dependent mitochondrial apoptotic pathway. Sarsasapogenin (60 μM)-induced ROS generation triggers ER stress and mitochondrial dysfunction[1]. Sarsasapogenin potently inhibits NF-κB and MAPK activation, as well as IRAK1, TAK1, and IκBα phosphorylation in LPS-stimulated macrophages. Moreover, Sarsasapogenin inhibits the binding of LPS to macrophage Toll-like receptor 4, and polarization of M2 to M1 macrophages[3].
In Vivo Sarsasapogenin (20 and 40 mg/kg) significantly restores the sucrose preference deficit induced by olfactory bulbectomy (OB), and increases locomotor activity. Sarsasapogenin groups (20 and 40 mg/kg) have significantly lower immobility times, higher AChE protein expression levels than the OB group. Furthermore, Sarsasapogenin (20 and 40 mg/kg) groups have significantly higher α7-nAChR protein expression, and increases higher α4-nAChR protein expression levels compared to rats in the OB group[2]. Sarsasapogenin (5 or 10 mg/kg, p.o.) inhibits TNBS-induced colon shortening and myeloperoxidase activity in mice, reducing NF-κB activation and interleukin (IL)-1β, tumor necrosis factor (TNF)-α, and IL-6 levels, while simultaneously increasing IL-10[3].
Cell Assay The effect of Sarsasapogenin on cell viability is measured by the MTT assay method. After exposure to Sarsasapogenin in the absence or presence of Z-VAD-FMK pretreatment for the indicated time, cells in 96-well plates are incubated with MTT. The formazan precipitate is dissolved in 200 μL of dimethyl sulfoxide, and the absorbance at 570 nm is measured using a Benchmark microplate reader.
Animal Admin The mice are randomly divided into 7 groups: normal control, TNBS-induced colitic control groups treated with vehicle, timosaponin AIII (5 or 10 mg/kg), Sarsasapogenin (5 or 10 mg/kg) or sulfasalazine (50 mg/kg). Each group consists of 6 mice. The colitis is induced by the intrarectal injection of 2.5% (w/v) TNBS solution (100 μL, dissolved in 50% ethanol) into the colon of anesthetized mice using a thin round-tip needle equipped with a syringe. The normal group is treated with vehicle alone instead of TNBS and test agents. If the injected TNBS solution is excreted, the mouse is excluded from the experiment. Timosaponin AIII or Sarsasapogenin (5 or 10 mg/kg) or sulfasalazine (50 mg/kg) dissolved in 2% tween 80 are orally administered once a day for 3 days after treatment with TNBS. The mice are killed 18 h after the final administration of test agents. The colon is quickly removed, opened longitudinally, and gently washed by PBS. Macroscopic evaluation of the colitis grade is scored (0, no ulcer and no inflammation; 1, no ulceration and local hyperemia; 2, ulceration with hyperemia; 3, ulceration and inflammation at one site only; 4, two or more sites of ulceration and inflammation; 5, ulceration extending more than 2 cm). The colons are stored at −80°C until used in the experiment for ELISA and immunoblotting.
References

[1]. Shen S, et al. Sarsasapogenin induces apoptosis via the reactive oxygen species-mediated mitochondrial pathway and ER stress pathway in HeLa cells. Biochem Biophys Res Commun. 2013 Oct 26.

[2]. Feng B, et al. Sarsasapogenin reverses depressive-like behaviors and nicotinic acetylcholine receptors induced by olfactory bulbectomy. Neurosci Lett. 2017 Feb 3;639:173-178.

[3]. Lim SM, et al. Timosaponin AIII and its metabolite sarsasapogenin ameliorate colitis in mice by inhibiting NF-κB and MAPK activation and restoring Th17/Treg cell balance. Int Immunopharmacol. 2015 Apr;25(2):493-503.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 516.6±20.0 °C at 760 mmHg
Melting Point 194°C
Molecular Formula C27H44O3
Molecular Weight 416.637
Flash Point 266.2±21.8 °C
Exact Mass 416.329041
PSA 38.69000
LogP 6.21
Vapour Pressure 0.0±3.0 mmHg at 25°C
Index of Refraction 1.552

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes T+
RIDADR NONH for all modes of transport
WGK Germany 3

 Synthetic Route

 Articles27

More Articles
Regioselective cleavage of 22-oxo-23-spiroketals. Novel cholestanic frameworks with pyranone and cyclopentenone E rings on the side chain.

Steroids 77(5) , 534-41, (2012)

The regioselective opening of the F ring of 22-oxo-23-spiroketals using a saturated solution of HCl in acetic anhydride yielded novel cholestanic frameworks with pyranone or cyclopentenone E rings. Th...
Deacylation reactions of 20-acetyl dinorcholanic lactones and 20,23-diacetyl furost-22-enes.

Steroids 75(3) , 240-4, (2010)

We report the deacylation of (20R)-20-acetyl-23,24-dinorcholanic lactones by hydrazine hydrate, under microwave irradiation in high yields. The elimination of the 20-acetyl group proceeded with retent...
Sarsasapogenin induces apoptosis via the reactive oxygen species-mediated mitochondrial pathway and ER stress pathway in HeLa cells.

Biochem. Biophys. Res. Commun. 441(2) , 519-24, (2013)

Sarsasapogenin is a sapogenin from the Chinese medical herb Anemarrhena asphodeloides Bunge. In the present study, we revealed that sarsasapogenin exhibited antitumor activity by inducing apoptosis in...

 Synonyms

Spirostan-3-ol, (3β,5β,25S)-
PERIGENIN
5β-Spirostan-3β-ol, (25S)-
PARIGENIN
MFCD00075412
SARSAPOGENINE
EINECS 204-776-3
(2S,4aS,4bS,5'S,6aS,6bR,7S,8R,9aS,10aS,10bR,12aR)-4a,5',6a,7-Tetramethyldocosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-8,2'-pyran]-2-ol
Sasarasapogenin
(2S,4aS,4bS,5'S,6aS,6bR,7S,8R,9aS,10aS,10bR,12aR)-4a,5',6a,7-Tétraméthyldocosahydrospiro[naphto[2',1':4,5]indéno[2,1-b]furane-8,2'-pyran]-2-ol
(3β,5β,25S)-Spirostan-3-ol
Yucca Extract
SARSAPOGENIN
(25S)-5beta-spirostan-3beta-ol
(3b,5b,25S)-Spirostan-3-ol
Yucca foam extract
sarsagenin
Sarsasapogenin
(25S)-Spirostan-3β-ol
Top Suppliers:I want be here
  • BioBioPha
  • China
  • Product Name: Sarsasapogenin
  • Price: ￥Inquiry/50mg
  • Purity: 98.0%
  • Stocking Period: 1 Day
  • Contact: Xueping-Zheng

Get all suppliers and price by the below link:

Sarsasapogenin suppliers

Price: ￥3120/100mg

Reference only. check more Sarsasapogenin price

Related Compounds: More...
sarsasapogenin
6788-40-5
epi-Sarsasapogenin
470-03-1
sarsasapogenin acetate
35319-91-6
Chemsrc provides Sarsasapogenin(CAS#:126-19-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Sarsasapogenin are included as well.>> amp version: Sarsasapogenin

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved