PHCCC(4Me)

Modify Date: 2025-08-24 23:05:13

PHCCC(4Me) Structure
PHCCC(4Me) structure
Common Name PHCCC(4Me)
CAS Number 1259532-01-8 Molecular Weight 308.33
Density N/A Boiling Point N/A
Molecular Formula C18H16N2O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of PHCCC(4Me)


PHCCC(4Me) (THCCC), a PHCCC analog, is a dual mGluR2 (IC50 of 1.5 μM) negative allosteric modulator and mGluR3 (EC50 of 8.9 μM) positive allosteric modulator[1].

 Names

Name PHCCC(4Me)

 PHCCC(4Me) Biological Activity

Description PHCCC(4Me) (THCCC), a PHCCC analog, is a dual mGluR2 (IC50 of 1.5 μM) negative allosteric modulator and mGluR3 (EC50 of 8.9 μM) positive allosteric modulator[1].
Related Catalog
In Vitro PHCCC(4Me) (THCCC; Compound 3) shows micromolar affinityfor mGluR2, with a Ki value of 0.6 μM[1].
References

[1]. Stephan Schann, et al. Chemical switch of a metabotropic glutamate receptor 2 silent allosteric modulator into dual metabotropic glutamate receptor 2/3 negative/positive allosteric modulators. J Med Chem. 2010 Dec 23;53(24):8775-9.

 Chemical & Physical Properties

Molecular Formula C18H16N2O3
Molecular Weight 308.33
InChIKey VKCTUZKPBYSTDW-CAPFRKAQSA-N
SMILES Cc1ccc(NC(=O)C23CC2C(=NO)c2ccccc2O3)cc1
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