PHCCC(4Me)

Names

[ Name ]:
PHCCC(4Me)

Biological Activity

[Description]:

PHCCC(4Me) (THCCC), a PHCCC analog, is a dual mGluR2 (IC50 of 1.5 μM) negative allosteric modulator and mGluR3 (EC50 of 8.9 μM) positive allosteric modulator[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> mGluR

Research Areas >> Neurological Disease

[In Vitro]

PHCCC(4Me) (THCCC; Compound 3) shows micromolar affinityfor mGluR2, with a Ki value of 0.6 μM[1].

[References]

[1]. Stephan Schann, et al. Chemical switch of a metabotropic glutamate receptor 2 silent allosteric modulator into dual metabotropic glutamate receptor 2/3 negative/positive allosteric modulators. J Med Chem. 2010 Dec 23;53(24):8775-9.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₁₆N₂O₃

[ Molecular Weight ]:
308.33

Related Compounds

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