Myosin V-IN-1

Modify Date: 2024-01-19 17:34:44

Myosin V-IN-1 Structure
Myosin V-IN-1 structure
Common Name Myosin V-IN-1
CAS Number 1259177-59-7 Molecular Weight 538.62
Density N/A Boiling Point N/A
Molecular Formula C29H26N6O3S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Myosin V-IN-1


Myosin V-IN-1 (compound 8) is a potent and selective Myosin V inhibitor, with a Ki of 6 μM. Myosin V-IN-1 shows acute inhibition of myosin V. Myosin V-IN-1 slows the actin-activated myosin V ATPase by specifically inhibiting ADP release from the actomyosin complex[1][2].

 Names

Name Myosin V-IN-1

 Myosin V-IN-1 Biological Activity

Description Myosin V-IN-1 (compound 8) is a potent and selective Myosin V inhibitor, with a Ki of 6 μM. Myosin V-IN-1 shows acute inhibition of myosin V. Myosin V-IN-1 slows the actin-activated myosin V ATPase by specifically inhibiting ADP release from the actomyosin complex[1][2].
Related Catalog
In Vitro Myosin V-IN-1 (compound 8) 显示出单头肌球蛋白 V 稳态肌动蛋白激活 ATP 水解速率的剂量依赖性降低[1]。
References

[1]. Maschi D, et al. Myosin V Regulates Spatial Localization of Different Forms of Neurotransmitter Release in Central Synapses. Front Synaptic Neurosci. 2021 Apr 15;13:650334.  

[2]. Islam K, et al. A myosin V inhibitor based on privileged chemical scaffolds. Angew Chem Int Ed Engl. 2010 Nov 2;49(45):8484-8.

 Chemical & Physical Properties

Molecular Formula C29H26N6O3S
Molecular Weight 538.62
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