Myosin V-IN-1

Names

[ Name ]:
Myosin V-IN-1

Biological Activity

[Description]:

Myosin V-IN-1 (compound 8) is a potent and selective Myosin V inhibitor, with a Ki of 6 μM. Myosin V-IN-1 shows acute inhibition of myosin V. Myosin V-IN-1 slows the actin-activated myosin V ATPase by specifically inhibiting ADP release from the actomyosin complex[1][2].

[Related Catalog]:

Signaling Pathways >> Cytoskeleton >> Myosin

Research Areas >> Neurological Disease

[In Vitro]

Myosin V-IN-1 (compound 8) 显示出单头肌球蛋白 V 稳态肌动蛋白激活 ATP 水解速率的剂量依赖性降低[1]。

[References]

[1]. Maschi D, et al. Myosin V Regulates Spatial Localization of Different Forms of Neurotransmitter Release in Central Synapses. Front Synaptic Neurosci. 2021 Apr 15;13:650334.

[2]. Islam K, et al. A myosin V inhibitor based on privileged chemical scaffolds. Angew Chem Int Ed Engl. 2010 Nov 2;49(45):8484-8.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₉H₂₆N₆O₃S

[ Molecular Weight ]:
538.62

Related Compounds

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