Nusinersen

Modify Date: 2025-08-20 12:36:07

Nusinersen structure	Common Name	Nusinersen
	CAS Number	1258984-36-9	Molecular Weight	7127.194237
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₃₄H₃₄₀N₆₁O₁₂₈P₁₇S₁₇	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Nusinersen

Nusinersen is an antisense oligonucleotide drug that modifies pre–messenger RNA splicing of the SMN2 gene and thus promotes increased production of full-length SMN protein[1].

Name	Nusinersen
Synonym	More Synonyms

Description	Nusinersen is an antisense oligonucleotide drug that modifies pre–messenger RNA splicing of the SMN2 gene and thus promotes increased production of full-length SMN protein[1].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis Research Areas >> Inflammation/Immunology
In Vitro	Nusinersen is an SMN-ASO that increases SMN levels by blocking an intronic splice silencer in SMN2, thereby facilitating the exon 7 inclusion and generation of FL-SMN2 transcripts[2].
References	[1]. Richard S Finkel, et al. Nusinersen versus Sham Control in Infantile-Onset Spinal Muscular Atrophy. N Engl J Med. 2017 Nov 2;377(18):1723-1732. [2]. Laura Torres-Benito, et al. NCALD Antisense Oligonucleotide Therapy in Addition to Nusinersen further Ameliorates Spinal Muscular Atrophy in Mice. Am J Hum Genet. 2019 Jul 3;105(1):221-230.

Molecular Formula	C₂₃₄H₃₄₀N₆₁O₁₂₈P₁₇S₁₇
Molecular Weight	7127.194237
InChIKey	WWFDJIVIDXJAQR-FFWSQMGZSA-N
SMILES	COCCOC1C(OP(O)(=S)OCC2OC(n3cnc4c(N)ncnc43)C(OCCOC)C2OP(O)(=S)OCC2OC(n3cc(C)c(N)nc3=O)C(OCCOC)C2OP(O)(=S)OCC2OC(n3cc(C)c(=O)[nH]c3=O)C(OCCOC)C2OP(O)(=S)OCC2OC(n3cc(C)c(=O)[nH]c3=O)C(OCCOC)C2OP(O)(=S)OCC2OC(n3cc(C)c(=O)[nH]c3=O)C(OCCOC)C2OP(O)(=S)OCC2OC(n3cc(C)c(N)nc3=O)C(OCCOC)C2OP(O)(=S)OCC2OC(n3cnc4c(N)ncnc43)C(OCCOC)C2OP(O)(=S)OCC2OC(n3cc(C)c(=O)[nH]c3=O)C(OCCOC)C2OP(O)(=S)OCC2OC(n3cnc4c(N)ncnc43)C(OCCOC)C2OP(O)(=S)OCC2OC(n3cnc4c(N)ncnc43)C(OCCOC)C2OP(O)(=S)OCC2OC(n3cc(C)c(=O)[nH]c3=O)C(OCCOC)C2OP(O)(=S)OCC2OC(n3cnc4c(=O)[nH]c(N)nc43)C(OCCOC)C2OP(O)(=S)OCC2OC(n3cc(C)c(N)nc3=O)C(OCCOC)C2OP(O)(=S)OCC2OC(n3cc(C)c(=O)[nH]c3=O)C(OCCOC)C2OP(O)(=S)OCC2OC(n3cnc4c(=O)[nH]c(N)nc43)C(OCCOC)C2OP(O)(=S)OCC2OC(n3cnc4c(=O)[nH]c(N)nc43)C(OCCOC)C2O)C(COP(O)(=S)OC2C(CO)OC(n3cc(C)c(=O)[nH]c3=O)C2OCCOC)OC1n1cc(C)c(N)nc1=O
Storage condition	-20°C

Nusinersen

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Nusinersen
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: Nusinersen
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Delivery: 1 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Nusinersen
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.