ACT-389949

Modify Date: 2025-08-25 18:06:18

ACT-389949 Structure
ACT-389949 structure
 Common Name ACT-389949
CAS Number 1258417-54-7 Molecular Weight 428.39
Density N/A Boiling Point N/A
Molecular Formula C20H18F2N6O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of ACT-389949


ACT-389949 is a first-in-class, potent and selective and agonist of formyl peptide receptor type 2 (FPR2)/Lipoxin A4 receptor (ALX), with an EC50 of 3 nM for FPR2/ALX internalization into monocytes. ACT-389949 has potential for the treatment of inflammatory disorders[1][2].

 Names

Name ACT-389949

 ACT-389949 Biological Activity

Description ACT-389949 is a first-in-class, potent and selective and agonist of formyl peptide receptor type 2 (FPR2)/Lipoxin A4 receptor (ALX), with an EC50 of 3 nM for FPR2/ALX internalization into monocytes. ACT-389949 has potential for the treatment of inflammatory disorders[1][2].
Related Catalog
Target

(FPR2)/(ALX)[1]

In Vivo ACT-389949 has well tolerated. Maximum concentrations are reached around 2 hours after dosing, with a mean terminal half-life of 29.3 hours[1]. Administration of ACT-389949 results in a dose-dependent, long-lasting internalization of FPR2/ALX into leukocytes[1].
References

[1]. Stalder AK,et al. Biomarker-guided clinical development of the first-in-class anti-inflammatory FPR2/ALX agonist ACT-389949. Br J Clin Pharmacol. 2017 Mar;83(3):476-486.

[2]. Lind S, et al. Functional and signaling characterization of the neutrophil FPR2 selective agonist Act-389949. Biochem Pharmacol. 2019 Aug;166:163-173.

 Chemical & Physical Properties

Molecular Formula C20H18F2N6O3
Molecular Weight 428.39
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Chemsrc provides ACT-389949(CAS#:1258417-54-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of ACT-389949 are included as well.>> amp version: ACT-389949

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