ACT-389949
Modify Date: 2025-08-25 18:06:18
ACT-389949 structure
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Common Name | ACT-389949 | ||
|---|---|---|---|---|
| CAS Number | 1258417-54-7 | Molecular Weight | 428.39 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H18F2N6O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ACT-389949ACT-389949 is a first-in-class, potent and selective and agonist of formyl peptide receptor type 2 (FPR2)/Lipoxin A4 receptor (ALX), with an EC50 of 3 nM for FPR2/ALX internalization into monocytes. ACT-389949 has potential for the treatment of inflammatory disorders[1][2]. |
| Name | ACT-389949 |
|---|
| Description | ACT-389949 is a first-in-class, potent and selective and agonist of formyl peptide receptor type 2 (FPR2)/Lipoxin A4 receptor (ALX), with an EC50 of 3 nM for FPR2/ALX internalization into monocytes. ACT-389949 has potential for the treatment of inflammatory disorders[1][2]. |
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| Related Catalog | |
| Target |
(FPR2)/(ALX)[1] |
| In Vivo | ACT-389949 has well tolerated. Maximum concentrations are reached around 2 hours after dosing, with a mean terminal half-life of 29.3 hours[1]. Administration of ACT-389949 results in a dose-dependent, long-lasting internalization of FPR2/ALX into leukocytes[1]. |
| References |
| Molecular Formula | C20H18F2N6O3 |
|---|---|
| Molecular Weight | 428.39 |
| InChIKey | PBTWPEDVIMHJEO-UHFFFAOYSA-N |
| SMILES | Cc1cccc(-c2oc(C)nc2C(=O)Nc2cnn(Cc3nc(C(C)(F)F)co3)n2)c1 |