1984890-99-4

1984890-99-4 structure

Name: ACT-451840
Chemical Name: ACT-451840
CAS Number: 1984890-99-4
Molecular Formula: C₄₇H₅₄N₆O₃
Molecular Weight: 750.97
Catalog: Research Areas Infection
Create Date: 2022-02-11 17:56:52
Modify Date: 2025-08-25 11:22:23
ACT-451840 is an orally active, potent and low-toxicity compound, showing activity against sensitive and resistant plasmodium falciparum strains. ACT-451840 targets all asexual blood stages of the parasite, has a rapid onset of action. ACT-451840 behaves in a way similar to artemisinin derivatives, with very rapid onset of action and elimination of parasite. ACT-451840 can be used for the research of malarial[1][2][3].

Name	ACT-451840
Synonyms	(2E)-N-[4-(4-Acetyl-1-piperazinyl)benzyl]-N-{(2S)-1-[4-(4-cyanobenzyl)-1-piperazinyl]-1-oxo-3-phenyl-2-propanyl}-3-[4-(2-methyl-2-propanyl)phenyl]acrylamide 2-Propenamide, N-[[4-(4-acetyl-1-piperazinyl)phenyl]methyl]-N-[(1S)-2-[4-[(4-cyanophenyl)methyl]-1-piperazinyl]-2-oxo-1-(phenylmethyl)ethyl]-3-[4-(1,1-dimethylethyl)phenyl]-, (2E)- ACT-451840 MFCD31700747

Description	ACT-451840 is an orally active, potent and low-toxicity compound, showing activity against sensitive and resistant plasmodium falciparum strains. ACT-451840 targets all asexual blood stages of the parasite, has a rapid onset of action. ACT-451840 behaves in a way similar to artemisinin derivatives, with very rapid onset of action and elimination of parasite. ACT-451840 can be used for the research of malarial[1][2][3].
Related Catalog	Research Areas >> Infection
In Vitro	ACT-451840 shows a 50 % inhibition concentration of 0.4 nM against the drug-sensitive P. falciparum NF54 strain. The IC50 value of ACT-451840 against the murine malaria parasite P. berghei is 13.5 nM in in vitro ex vivo assays.
In Vivo	ACT-451840 (10 and 60 mg kg) starts to show significant antimalarial effects (parasite reduction) in vivo at 20 mg/kg. ACT-451840 exhibits curative activity at 300 mg/kg and significant antimalarial effects already at 100 mg/kg. ACT-451840 shows excellent reduction at 30 mg/kg, resulting in 99.80 % activity[2]. ACT-451840 shows efficacy in the Plasmodium berghei mouse model[2].
References	[1]. Bruderer S, et al. First-in-humans study of the safety, tolerability, and pharmacokinetics of ACT-451840, a new chemical entity with antimalarial activity. Antimicrob Agents Chemother. 2015;59(2):935-942. [2]. Boss C, et al. Discovery and Characterization of ACT-451840: an Antimalarial Drug with a Novel Mechanism of Action. ChemMedChem. 2016;11(18):1995-2014. [3]. Le Bihan A, et al. Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose-Efficacy Modeling. PLoS Med. 2016;13(10):e1002138. Published 2016 Oct 4.

Density	1.2±0.1 g/cm3
Boiling Point	953.8±65.0 °C at 760 mmHg
Molecular Formula	C₄₇H₅₄N₆O₃
Molecular Weight	750.97
Flash Point	530.6±34.3 °C
Exact Mass	750.425720
LogP	6.74
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.652

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

1984890-99-4	2178049-58-4
1007392-69-9	1433875-14-9
1159501-31-1	1258417-54-7
1103522-45-7	1646267-59-5
121368-75-0	1159500-34-1
1082745-66-1	876743-01-0
1189771-22-9	1189858-98-7
297178-34-8	1314704-67-0
1270468-99-9	1311754-07-0
1072069-59-0	1189770-42-0