1433875-14-9

1433875-14-9 structure
1433875-14-9 structure
  • Name: ACT-373898
  • Chemical Name: ACT 373898
  • CAS Number: 1433875-14-9
  • Molecular Formula:
  • Molecular Weight:
  • Catalog: Research Areas Endocrinology
  • Create Date: 2018-06-20 09:27:04
  • Modify Date: 2024-01-08 22:07:50
  • ACT-373898 is an inactive carboxylic acid metabolite of Macitentan. Macitentan is an orally active, non-peptide dual ETA and ETB (endothelin receptor) antagonist[1].

Name ACT 373898
Description ACT-373898 is an inactive carboxylic acid metabolite of Macitentan. Macitentan is an orally active, non-peptide dual ETA and ETB (endothelin receptor) antagonist[1].
Related Catalog
In Vitro The elimination half-life (t1/2) is approximately 16 h for Macitentan, and ACT-373898 has a similar pharmacokinetic (PK) profile to Macitentan[1].
References

[1]. Shirin Bruderer, et al. Effect of cyclosporine and rifampin on the pharmacokinetics of macitentan, a tissue-targeting dual endothelin receptor antagonist. AAPS J. 2012 Mar;14(1):68-78.

No Any Chemical & Physical Properties