Lavendustin C

Modify Date: 2024-01-08 09:00:34

Lavendustin C structure	Common Name	Lavendustin C
	CAS Number	125697-93-0	Molecular Weight	275.257
	Density	1.6±0.1 g/cm3	Boiling Point	597.5±50.0 °C at 760 mmHg
	Molecular Formula	C₁₄H₁₃NO₅	Melting Point	193-195ºC dec.
	MSDS	Chinese USA	Flash Point	315.2±30.1 °C

Use of Lavendustin C

Lavendustin C is a potent Ca2+ calmodulin-dependent kinase II (CaMK II) inhibitor with an IC50 of 0.2 µM. Lavendustin C inhibits EGFR-associated tyrosine kinase (IC50=0.012 µM) and pp60c-src(+) kinase (IC50=0.5 µM) [1][2].

Name	lavendustin c
Synonym	More Synonyms

Description	Lavendustin C is a potent Ca2+ calmodulin-dependent kinase II (CaMK II) inhibitor with an IC50 of 0.2 µM. Lavendustin C inhibits EGFR-associated tyrosine kinase (IC50=0.012 µM) and pp60c-src(+) kinase (IC50=0.5 µM) [1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Neuronal Signaling >> CaMK Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Src
Target	CaMK II:0.2 μM (IC50) EGFR:0.012 μM (IC50)
In Vitro	Lavendustin C (Compound 5) shows potent inhibitory activity, and it may be the core structure responsible for inhibition of tyrosine kinase[1]. Lavendustin C (10-150 µM) inhibits tyrosine kinase-associated neutrophil degranulation and superoxide generation[3].
References	[1]. T Onoda, et al.Isolation of a Novel Tyrosine Kinase Inhibitor, Lavendustin A, From Streptomyces Griseolavendus. J Nat Prod. Nov-Dec 1989;52(6):1252-7. [2]. T J O'Dell, et al.Long-term Potentiation in the Hippocampus Is Blocked by Tyrosine Kinase Inhibitors. Nature. 1991 Oct 10;353(6344):558-60. [3]. H M Burt, et al. Inhibition of Crystal-Induced Neutrophil Activation by a Protein Tyrosine Kinase Inhibitor. J Leukoc Biol. 1994 Jan;55(1):112-9.

Density	1.6±0.1 g/cm3
Boiling Point	597.5±50.0 °C at 760 mmHg
Melting Point	193-195ºC dec.
Molecular Formula	C₁₄H₁₃NO₅
Molecular Weight	275.257
Flash Point	315.2±30.1 °C
Exact Mass	275.079376
PSA	110.02000
LogP	1.74
Vapour Pressure	0.0±1.8 mmHg at 25°C
Index of Refraction	1.759
Storage condition	-20℃

Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	26-36
HS Code	2922509090

2,5-Dihydroxybe...

CAS#:1194-98-5

Lavendustin C

CAS#:125697-93-0

Literature: Journal of Medicinal Chemistry, , vol. 37, # 24 p. 4079 - 4084

5-Aminosalicyli...

CAS#:89-57-6

Lavendustin C

CAS#:125697-93-0

Literature: Journal of Medicinal Chemistry, , vol. 37, # 24 p. 4079 - 4084

2,5-Dihydroxybe...

CAS#:1194-98-5

5-Aminosalicyli...

CAS#:89-57-6

Lavendustin C

CAS#:125697-93-0

Literature: Journal of Organic Chemistry, , vol. 61, # 26 p. 9368 - 9373

Precursor 2
CAS#:1194-98-5 2,5-Dihydroxybe... CAS#:89-57-6 5-Aminosalicyli...
DownStream 0

HS Code	2922509090
Summary	2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

5-[(2,5-Dihydroxybenzyl)amino]-2-hydroxybenzoic acid

Benzoic acid, 5-[[(2,5-dihydroxyphenyl)methyl]amino]-2-hydroxy-

hdba

compound 5

DC Chemicals Limited
China
Product Name: Lavendustin C (HDBA)
Price: $450.0/100mg $810.0/250mg $1620.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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