DBCO-PEG(4)-NH2
Modify Date: 2025-09-01 16:50:54
DBCO-PEG(4)-NH2 structure
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Common Name | DBCO-PEG(4)-NH2 | ||
|---|---|---|---|---|
| CAS Number | 1255942-08-5 | Molecular Weight | 523.621 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 784.1±60.0 °C at 760 mmHg | |
| Molecular Formula | C29H37N3O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 428.0±32.9 °C | |
Use of DBCO-PEG(4)-NH2DBCO-NHCO-PEG4-amine is a cleavable ADC linker used to conjugate MMAE (HY-15162) and antibody (e.g., DBCO-VCpAB−MMAE and DBCO-TRX−MMAE with EC50s of 280 nM and 22 nM in SKBR3 cells, respectively)[1]. |
| Name | 1-Amino-N-[3-(11,12-didehydrodibenzo[b,f]azocin-5(6H)-yl)-3-oxopropyl]-3,6,9,12-tetraoxapentadecan-15-amide |
|---|---|
| Synonym | More Synonyms |
| Description | DBCO-NHCO-PEG4-amine is a cleavable ADC linker used to conjugate MMAE (HY-15162) and antibody (e.g., DBCO-VCpAB−MMAE and DBCO-TRX−MMAE with EC50s of 280 nM and 22 nM in SKBR3 cells, respectively)[1]. |
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| Related Catalog | |
| Target |
Cleavable |
| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 784.1±60.0 °C at 760 mmHg |
| Molecular Formula | C29H37N3O6 |
| Molecular Weight | 523.621 |
| Flash Point | 428.0±32.9 °C |
| Exact Mass | 523.268250 |
| LogP | 1.56 |
| Vapour Pressure | 0.0±2.7 mmHg at 25°C |
| Index of Refraction | 1.595 |
| Hazard Codes | Xi |
|---|
| 3,6,9,12-Tetraoxapentadecan-15-amide, 1-amino-N-[3-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-3-oxopropyl]- |
| 1-Amino-N-[3-(11,12-didehydrodibenzo[b,f]azocin-5(6H)-yl)-3-oxopropyl]-3,6,9,12-tetraoxapentadecan-15-amide |