Lu AF-58027
Modify Date: 2025-09-23 19:48:34
Lu AF-58027 structure
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Common Name | Lu AF-58027 | ||
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| CAS Number | 1255919-63-1 | Molecular Weight | 486.62 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C28H34N6O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Lu AF-58027A novel potent, selective PDE1 inhibitor with IC50 of 13/45/1.4 nM for PDE1A/B/C, respectively; shows no signigicant inhibitory effects at other PDEs (at least micromolar concentrations); induces concentration-dependent relaxations reduced by ODQ and SQ22536 in rat isolated mesenteric arteries; dose-dependently lowers mean BP and increases heart rate in anaesthetized rats. |
| Name | Lu AF-58027 |
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| Description | A novel potent, selective PDE1 inhibitor with IC50 of 13/45/1.4 nM for PDE1A/B/C, respectively; shows no signigicant inhibitory effects at other PDEs (at least micromolar concentrations); induces concentration-dependent relaxations reduced by ODQ and SQ22536 in rat isolated mesenteric arteries; dose-dependently lowers mean BP and increases heart rate in anaesthetized rats. |
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| References | References 1. Laursen M, et al. Br J Pharmacol. 2017 Aug;174(15):2563-2575. View Related Products by Target Phosphodiesterase (PDE) |
| Molecular Formula | C28H34N6O2 |
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| Molecular Weight | 486.62 |