1255919-63-1
1255919-63-1 structure
- Name: Lu AF-58027
- Chemical Name: Lu AF-58027
- CAS Number: 1255919-63-1
- Molecular Formula: C28H34N6O2
- Molecular Weight: 486.62
- Create Date: 2020-01-11 16:57:49
- Modify Date: 2023-10-09 16:00:56
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A novel potent, selective PDE1 inhibitor with IC50 of 13/45/1.4 nM for PDE1A/B/C, respectively; shows no signigicant inhibitory effects at other PDEs (at least micromolar concentrations); induces concentration-dependent relaxations reduced by ODQ and SQ22536 in rat isolated mesenteric arteries; dose-dependently lowers mean BP and increases heart rate in anaesthetized rats.
| Name | Lu AF-58027 |
|---|
| Description | A novel potent, selective PDE1 inhibitor with IC50 of 13/45/1.4 nM for PDE1A/B/C, respectively; shows no signigicant inhibitory effects at other PDEs (at least micromolar concentrations); induces concentration-dependent relaxations reduced by ODQ and SQ22536 in rat isolated mesenteric arteries; dose-dependently lowers mean BP and increases heart rate in anaesthetized rats. |
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| References | References 1. Laursen M, et al. Br J Pharmacol. 2017 Aug;174(15):2563-2575. View Related Products by Target Phosphodiesterase (PDE) |
| Molecular Formula | C28H34N6O2 |
|---|---|
| Molecular Weight | 486.62 |