| Description |
Waltonitone is a ursane-type pentacyclic triterpene isolated from Gentian waltonii Burkill. Waltonitone significantly inhibits hepatocellular carcinoma cells growth and induces apoptosis in vitro and in vivo[1].
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| Related Catalog |
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| In Vitro |
waltonitone (10 μM, 25 μM; for 48 hours) results in an increment of sub-G1 population in BEL-7402 cells[1]. Waltonitone (25 μM; for 48 hours) induces BEL-7402 cells apoptosis[1]. Waltonitone (25 μM; for 48 hours) can effectively activate caspase-3 in BEL-7402 cells[1].
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| In Vivo |
Waltonitone (i.v.; 20 mg/kg or 50 mg/kg; once every two days for 16 days) inhibits BEL-7402 tumor growth in male athymic mice (BALB/c nu/nu) in vivo[1].
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| References |
[1]. Zhang Z, et al. Waltonitone induces human hepatocellular carcinoma cells apoptosis in vitro and in vivo.Cancer Lett. 2009 Dec 28;286(2):223-31.
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