Waltonitone

Names

[ Name ]:
Waltonitone

Biological Activity

[Description]:

Waltonitone is a ursane-type pentacyclic triterpene isolated from Gentian waltonii Burkill. Waltonitone significantly inhibits hepatocellular carcinoma cells growth and induces apoptosis in vitro and in vivo[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

[In Vitro]

waltonitone (10 μM, 25 μM; for 48 hours) results in an increment of sub-G1 population in BEL-7402 cells[1]. Waltonitone (25 μM; for 48 hours) induces BEL-7402 cells apoptosis[1]. Waltonitone (25 μM; for 48 hours) can effectively activate caspase-3 in BEL-7402 cells[1].

[In Vivo]

Waltonitone (i.v.; 20 mg/kg or 50 mg/kg; once every two days for 16 days) inhibits BEL-7402 tumor growth in male athymic mice (BALB/c nu/nu) in vivo[1].

[References]

[1]. Zhang Z, et al. Waltonitone induces human hepatocellular carcinoma cells apoptosis in vitro and in vivo.Cancer Lett. 2009 Dec 28;286(2):223-31.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₀H₄₈O₂

[ Molecular Weight ]:
440.70

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.