PTC725
Modify Date: 2023-01-17 08:31:33
PTC725 structure
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Common Name | PTC725 | ||
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| CAS Number | 1248581-07-8 | Molecular Weight | 518.487 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 701.2±70.0 °C at 760 mmHg | |
| Molecular Formula | C23H18F4N6O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 377.9±35.7 °C | |
Use of PTC725PTC725 is a potent, selective, and orally bioavailable inhibitor of HCV NS4B, inhibits HCV 1b (Con1) replicons with EC50 of 1.7 nM; displays a selectivity index of >5,000 with respect to cellular GAPDH, and >1,000-fold selectivity window with respect to cytotoxicity; retains fully activity against HCV replicon mutants that are resistant to inhibitors of NS3 protease and NS5B polymerase, demonstrates synergistic affect in combination with alpha interferon in vivo. |
| Name | 6-[3-Cyano-6-ethyl-5-fluoro-1-(2-pyrimidinyl)-1H-indol-2-yl]-N-[(2S)-1,1,1-trifluoro-2-propanyl]-3-pyridinesulfonamide |
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| Synonym | More Synonyms |
| Description | PTC725 is a potent, selective, and orally bioavailable inhibitor of HCV NS4B, inhibits HCV 1b (Con1) replicons with EC50 of 1.7 nM; displays a selectivity index of >5,000 with respect to cellular GAPDH, and >1,000-fold selectivity window with respect to cytotoxicity; retains fully activity against HCV replicon mutants that are resistant to inhibitors of NS3 protease and NS5B polymerase, demonstrates synergistic affect in combination with alpha interferon in vivo. |
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| References | References 1. Gu Z, et al. Antimicrob Agents Chemother. 2013 Jul;57(7):3250-61. 2. Zhang N, et al. J Med Chem. 2014 Mar 13;57(5):2121-35. 3. Graci JD, et al. Antimicrob Agents Chemother. 2016 Nov 21;60(12):7060-7066. View Related Products by Target HCV |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 701.2±70.0 °C at 760 mmHg |
| Molecular Formula | C23H18F4N6O2S |
| Molecular Weight | 518.487 |
| Flash Point | 377.9±35.7 °C |
| Exact Mass | 518.114807 |
| LogP | 4.28 |
| Vapour Pressure | 0.0±2.2 mmHg at 25°C |
| Index of Refraction | 1.638 |
| 3-Pyridinesulfonamide, 6-[3-cyano-6-ethyl-5-fluoro-1-(2-pyrimidinyl)-1H-indol-2-yl]-N-[(1S)-2,2,2-trifluoro-1-methylethyl]- |
| 6-[3-Cyano-6-ethyl-5-fluoro-1-(2-pyrimidinyl)-1H-indol-2-yl]-N-[(2S)-1,1,1-trifluoro-2-propanyl]-3-pyridinesulfonamide |