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PTC725

Names

[ CAS No. ]:
1248581-07-8

[ Name ]:
PTC725

[Synonym ]:
3-Pyridinesulfonamide, 6-[3-cyano-6-ethyl-5-fluoro-1-(2-pyrimidinyl)-1H-indol-2-yl]-N-[(1S)-2,2,2-trifluoro-1-methylethyl]-
6-[3-Cyano-6-ethyl-5-fluoro-1-(2-pyrimidinyl)-1H-indol-2-yl]-N-[(2S)-1,1,1-trifluoro-2-propanyl]-3-pyridinesulfonamide

Biological Activity

[Description]:

PTC725 is a potent, selective, and orally bioavailable inhibitor of HCV NS4B, inhibits HCV 1b (Con1) replicons with EC50 of 1.7 nM; displays a selectivity index of >5,000 with respect to cellular GAPDH, and >1,000-fold selectivity window with respect to cytotoxicity; retains fully activity against HCV replicon mutants that are resistant to inhibitors of NS3 protease and NS5B polymerase, demonstrates synergistic affect in combination with alpha interferon in vivo.

[References]

References 1. Gu Z, et al. Antimicrob Agents Chemother. 2013 Jul;57(7):3250-61. 2. Zhang N, et al. J Med Chem. 2014 Mar 13;57(5):2121-35. 3. Graci JD, et al. Antimicrob Agents Chemother. 2016 Nov 21;60(12):7060-7066. View Related Products by Target HCV

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
701.2±70.0 °C at 760 mmHg

[ Molecular Formula ]:
C23H18F4N6O2S

[ Molecular Weight ]:
518.487

[ Flash Point ]:
377.9±35.7 °C

[ Exact Mass ]:
518.114807

[ LogP ]:
4.28

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.638

Related Compounds