Pitofenone hydrochloride

Modify Date: 2024-03-03 14:09:51

Pitofenone hydrochloride structure	Common Name	Pitofenone hydrochloride
	CAS Number	1248-42-6	Molecular Weight	403.89900
	Density	N/A	Boiling Point	512ºC at 760 mmHg
	Molecular Formula	C₂₂H₂₆ClNO₄	Melting Point	N/A
	MSDS	N/A	Flash Point	263.4ºC

Use of Pitofenone hydrochloride

Pitofenone hydrochloride, a spasmolytic compound, inhibits the acetylcholinesterase (AChE) activity from bovine erythrocytes and from electric eel with Kis of 36 and 45 μM, respectively.

Name	methyl 2-[4-[2-piperidinoethoxy]benzoyl]benzoate hydrochloride
Synonym	More Synonyms

Description	Pitofenone hydrochloride, a spasmolytic compound, inhibits the acetylcholinesterase (AChE) activity from bovine erythrocytes and from electric eel with Kis of 36 and 45 μM, respectively.
Related Catalog	Signaling Pathways >> Neuronal Signaling >> AChE Research Areas >> Neurological Disease
Target	Ki: 36 μM (AChE, bovine erythrocytes), 45 μM (AChE, electric eel)
References	[1]. Punekar NS, et al. Acetylcholinesterase inhibition by pitofenone: a spasmolytic compound. Biotechnol Appl Biochem. 1991 Dec;14(3):378-82.

Boiling Point	512ºC at 760 mmHg
Molecular Formula	C₂₂H₂₆ClNO₄
Molecular Weight	403.89900
Flash Point	263.4ºC
Exact Mass	403.15500
PSA	55.84000
LogP	4.30880
Vapour Pressure	1.35E-10mmHg at 25°C
Storage condition	2-8℃

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DH6477800

CHEMICAL NAME :: Benzoic acid, o-(p-(2-piperidinoethoxy)benzoyl)-, methyl ester, hydrochloride

CAS REGISTRY NUMBER :: 1248-42-6

LAST UPDATED :: 198912

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C22-H25-N-O4.Cl-H

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TKZGAG Trudove na Nauchnoizsledovatelskiya Khimiko-Farmatsevtichen Institut. Transactions of the Scientific Research Chemico-Pharmaceutical Institute. (Durzhavno Izdatelstvo Tekhnika, Bul. Russki 6, Sofia Bulgaria) V.4- 1963 Volume(issue)/page/year: 15,211,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 125 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TKZGAG Trudove na Nauchnoizsledovatelskiya Khimiko-Farmatsevtichen Institut. Transactions of the Scientific Research Chemico-Pharmaceutical Institute. (Durzhavno Izdatelstvo Tekhnika, Bul. Russki 6, Sofia Bulgaria) V.4- 1963 Volume(issue)/page/year: 15,211,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 690 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TKZGAG Trudove na Nauchnoizsledovatelskiya Khimiko-Farmatsevtichen Institut. Transactions of the Scientific Research Chemico-Pharmaceutical Institute. (Durzhavno Izdatelstvo Tekhnika, Bul. Russki 6, Sofia Bulgaria) V.4- 1963 Volume(issue)/page/year: 15,211,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TKZGAG Trudove na Nauchnoizsledovatelskiya Khimiko-Farmatsevtichen Institut. Transactions of the Scientific Research Chemico-Pharmaceutical Institute. (Durzhavno Izdatelstvo Tekhnika, Bul. Russki 6, Sofia Bulgaria) V.4- 1963 Volume(issue)/page/year: 15,211,1985

HS Code	2933399090

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

2-[4-(2-Piperidino-aethoxy)-benzoyl]-benzoesaeure-methylester,Hydrochlorid

methyl 2-[4-(2-piperidin-1-ylethoxy)benzoyl]benzoate hydrochloride

2-[4-(2-piperidino-ethoxy)-benzoyl]-benzoic acid methyl ester,hydrochloride

pitofenone hydrochloride

methyl 2-[4-(2-piperidin-1-ylethoxy)phenyl]carbonylbenzoate hydrochloride

methyl 2-[4-(2-piperidinoethoxy)benzoyl]benzoate hydrochloride

DC Chemicals Limited
China
Product Name: Pitofenone hydrochloride
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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Price: $88/10mM*1mLinDMSO

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