Propiconazole-d7

Modify Date: 2024-01-20 10:33:50

Propiconazole-d7 structure	Common Name	Propiconazole-d7
	CAS Number	1246818-14-3	Molecular Weight	349.263
	Density	1.4±0.1 g/cm3	Boiling Point	480.0±55.0 °C at 760 mmHg
	Molecular Formula	C₁₅H₁₀D₇Cl₂N₃O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	244.1±31.5 °C

Use of Propiconazole-d7

Propiconazole-d7 is the deuterium labeled Propiconazole. Propiconazole is a broad-spectrum triazole fungicide that inhibits the conversion of lanosterol to ergosterol, leading to fungal cell membrane disruption. Propiconazole inhibits S. cerevisiae, but not rat liver, microsomal cytochrome P450 (IC50s=0.04 and >200 µM, respectively). Propiconazole inhibits the growth of T. deformans and R. stolonifer (ED50s=0.073 and 4.6 µg/mL, respectively). Propiconazole increases production of reactive oxygen species (ROS)[1].

Name	Propiconazole-d7
Synonym	More Synonyms

Description	Propiconazole-d7 is the deuterium labeled Propiconazole. Propiconazole is a broad-spectrum triazole fungicide that inhibits the conversion of lanosterol to ergosterol, leading to fungal cell membrane disruption. Propiconazole inhibits S. cerevisiae, but not rat liver, microsomal cytochrome P450 (IC50s=0.04 and >200 µM, respectively). Propiconazole inhibits the growth of T. deformans and R. stolonifer (ED50s=0.073 and 4.6 µg/mL, respectively). Propiconazole increases production of reactive oxygen species (ROS)[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Teng M, et al. Effect of Propiconazole on the Lipid Metabolism of Zebrafish Embryos ( Danio rerio). J Agric Food Chem. 2019;67(16):4623-4631. [2]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

Density	1.4±0.1 g/cm3
Boiling Point	480.0±55.0 °C at 760 mmHg
Molecular Formula	C₁₅H₁₀D₇Cl₂N₃O₂
Molecular Weight	349.263
Flash Point	244.1±31.5 °C
Exact Mass	348.113708
LogP	3.88
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.624

Propiconazole-d7

1-{[2-(2,4-Dichlorophenyl)-4-(2H7)propyl-1,3-dioxolan-2-yl]methyl}-1H-1,2,4-triazole

1H-1,2,4-Triazole, 1-[[2-(2,4-dichlorophenyl)-4-(propyl-d7)-1,3-dioxolan-2-yl]methyl]-

Propiconazole-d7

Use of Propiconazole-d7

Names

Propiconazole-d7 Biological Activity

Chemical & Physical Properties

Synonyms