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Propiconazole-d7

Names

[ CAS No. ]:
1246818-14-3

[ Name ]:
Propiconazole-d7

[Synonym ]:
Propiconazole-d7
1-{[2-(2,4-Dichlorophenyl)-4-(2H7)propyl-1,3-dioxolan-2-yl]methyl}-1H-1,2,4-triazole
1H-1,2,4-Triazole, 1-[[2-(2,4-dichlorophenyl)-4-(propyl-d7)-1,3-dioxolan-2-yl]methyl]-

Biological Activity

[Description]:

Propiconazole-d7 is the deuterium labeled Propiconazole. Propiconazole is a broad-spectrum triazole fungicide that inhibits the conversion of lanosterol to ergosterol, leading to fungal cell membrane disruption. Propiconazole inhibits S. cerevisiae, but not rat liver, microsomal cytochrome P450 (IC50s=0.04 and >200 µM, respectively). Propiconazole inhibits the growth of T. deformans and R. stolonifer (ED50s=0.073 and 4.6 µg/mL, respectively). Propiconazole increases production of reactive oxygen species (ROS)[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Fungal

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Teng M, et al. Effect of Propiconazole on the Lipid Metabolism of Zebrafish Embryos ( Danio rerio). J Agric Food Chem. 2019;67(16):4623-4631.

[2]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
480.0±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C15H10D7Cl2N3O2

[ Molecular Weight ]:
349.263

[ Flash Point ]:
244.1±31.5 °C

[ Exact Mass ]:
348.113708

[ LogP ]:
3.88

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.624

Related Compounds