N-desmethyl Enzalutamide
Modify Date: 2024-01-02 14:42:35
N-desmethyl Enzalutamide structure
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Common Name | N-desmethyl Enzalutamide | ||
|---|---|---|---|---|
| CAS Number | 1242137-16-1 | Molecular Weight | 450.40900 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H14F4N4O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of N-desmethyl EnzalutamideN-desmethyl Enzalutamide is the active metabolite of Enzalutamide. Enzalutamide is an androgen-receptor (AR) antagonist with IC50 of 36 nM in LNCaP cells. |
| Name | N-Desmethylenzalutamide |
|---|---|
| Synonym | More Synonyms |
| Description | N-desmethyl Enzalutamide is the active metabolite of Enzalutamide. Enzalutamide is an androgen-receptor (AR) antagonist with IC50 of 36 nM in LNCaP cells. |
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| Related Catalog | |
| Target |
Androgen-receptor[1] |
| In Vivo | N-desmethyl Enzalutamide is an active metabolite that is thought to contribute to the clinical effects of Enzalutamide because it demonstrates primary and secondary pharmacodynamics of similar potency to Enzalutamide and circulates at approximately the same plasma concentrations as Enzalutamide. The carboxylic acid metabolite is pharmacologically inactive and circulates at approximately 25 % lower plasma concentrations than Enzalutamide[1]. |
| References |
| Molecular Formula | C20H14F4N4O2S |
|---|---|
| Molecular Weight | 450.40900 |
| Exact Mass | 450.07700 |
| PSA | 122.52000 |
| LogP | 4.56208 |
| Storage condition | 2-8℃ |
| N-desmethyl Enzalutamide |
| Enzalutamide Impurity 2 |