N-desmethyl Enzalutamide
Names
[ CAS No. ]:
1242137-16-1
[ Name ]:
N-desmethyl Enzalutamide
[Synonym ]:
N-desmethyl Enzalutamide
Enzalutamide Impurity 2
Biological Activity
[Description]:
N-desmethyl Enzalutamide is the active metabolite of Enzalutamide. Enzalutamide is an androgen-receptor (AR) antagonist with IC50 of 36 nM in LNCaP cells.
[Related Catalog]:
[Target]
Androgen-receptor[1]
[In Vivo]
N-desmethyl Enzalutamide is an active metabolite that is thought to contribute to the clinical effects of Enzalutamide because it demonstrates primary and secondary pharmacodynamics of similar potency to Enzalutamide and circulates at approximately the same plasma concentrations as Enzalutamide. The carboxylic acid metabolite is pharmacologically inactive and circulates at approximately 25 % lower plasma concentrations than Enzalutamide[1].
[References]
[Related Small Molecules]
ARN-509
|
Dehydroepiandrosterone
|
Flutamide
|
ODM-201
|
Danazol
|
3,3'-Diindolylmethane
|
AZD3514
|
RAD140
|
BMS-564929
|
GLPG0492
|
Cyproterone acetate
|
LGD-4033
|
Lupeol
|
Andarine
|
MK-0773
Chemical & Physical Properties
[ Molecular Formula ]:
C20H14F4N4O2S
[ Molecular Weight ]:
450.40900
[ Exact Mass ]:
450.07700
[ PSA ]:
122.52000
[ LogP ]:
4.56208
[ Storage condition ]:
2-8℃