GLYCOL CHITOSAN

Modify Date: 2024-01-02 09:19:11

GLYCOL CHITOSAN Structure
GLYCOL CHITOSAN structure
Common Name GLYCOL CHITOSAN
CAS Number 123938-86-3 Molecular Weight N/A
Density N/A Boiling Point N/A
Molecular Formula N/A Melting Point N/A
MSDS USA Flash Point N/A

 Use of GLYCOL CHITOSAN


Glycol chitosan is a chitosan derivative with hydrophilic ethylene glycol branches. Glycol chitosan enhances membrane permeability and leadkage in Glycine max Harosoy 63W cells. Glycol chitosan is water-soluble, biocompatible and biodegradable[1][2][3]. Glycol chitosan inhibits E. coli, S. aureus and S. enteritidis growths with MIC values of 4 μg/mL, 32 μg/mL and <0.5 μg/mL, respectively[4].

 Names

Name GLYCOL CHITOSAN
Synonym More Synonyms

 GLYCOL CHITOSAN Biological Activity

Description Glycol chitosan is a chitosan derivative with hydrophilic ethylene glycol branches. Glycol chitosan enhances membrane permeability and leadkage in Glycine max Harosoy 63W cells. Glycol chitosan is water-soluble, biocompatible and biodegradable[1][2][3]. Glycol chitosan inhibits E. coli, S. aureus and S. enteritidis growths with MIC values of 4 μg/mL, 32 μg/mL and <0.5 μg/mL, respectively[4].
Related Catalog
Target

MIC: 4 μg/mL (E. coli), 32 μg/mL (S. aureus) and <0.5 μg/mL (S. enteritidis)[4]

In Vitro Glycol chitosan derivatives have been successfully applied to deliver antimicrobial agents and anticancer drugs such as chemodrugs, genes, and photosensitizers (PSs), either by physical encapsulation or chemical conjugation. Glycol chitosan can be directly linked with hydrophobic drugs to generate amphiphilic compounds that can also form nanoparticles (NPs) for cell imaging and drug delivery. The use of Glycol chitosan derivatives for cell imaging and drug delivery has several advantages, including superb tumor-homing ability in the case of Glycol chitosan NPs based on enhanced permeability and retention (EPR) effect, low cytotoxicity, ease of chemical modification, great biocompatibility, and biodegradability[1]. The hydrophobic modification of Glycol chitosan is already confirmed, such as Glycol chitosan bearing a 5β-cholanic acid moiety and deoxycholic acid-Glycol chitosan, could self-assemble into nanoparticles, acting as a promising vehicle for hydrophobic drugs and genes[2].
References

[1]. Lin F, et al. Glycol Chitosan: A Water-Soluble Polymer for Cell Imaging and Drug Delivery. Molecules. 2019 Nov 29;24(23). pii: E4371.

[2]. Yu A, et al. Mucoadhesive dexamethasone-glycol chitosan nanoparticles for ophthalmic drug delivery. Int J Pharm. 2020 Feb 15;575:118943.

[3]. Young DH, et al. Effect of Chitosan on Membrane Permeability of Suspension-Cultured Glycine max and Phaseolus vulgaris Cells. Plant Physiol. 1982 Nov;70(5):1449-54.

[4]. Stephen Inbaraj B, et al.Synthesis, characterization and antibacterial activity of superparamagnetic nanoparticles modified with glycol chitosan.Sci Technol Adv Mater. 2012 Feb 2;13(1):015002.

 Chemical & Physical Properties

Appearance of Characters crystalline
Storage condition −20°C

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
RIDADR NONH for all modes of transport
WGK Germany 3

 Articles3

More Articles
Effect of Chitosan on Membrane Permeability of Suspension-Cultured Glycine max and Phaseolus vulgaris Cells.

Plant Physiol. 70 , 1449-1454, (1982)

Treatment of suspension-cultured Glycine max cv Harosoy 63 cells with soluble chitosan (20-500 micrograms per milliliter) increased membrane permeability as shown by leakage of electrolytes, protein, ...

Pilot in vivo toxicological investigation of boron nitride nanotubes.

Int. J. Nanomedicine 7 , 19-24, (2012)

Boron nitride nanotubes (BNNTs) have attracted huge attention in many different research fields thanks to their outstanding chemical and physical properties. During recent years, our group has pioneer...

Barium Titanate Nanoparticles: Highly Cytocompatible Dispersions in Glycol-chitosan and Doxorubicin Complexes for Cancer Therapy.

Nanoscale Res. Lett. 5 , 1093-101, (2011)

In the latest years, innovative nanomaterials have attracted a dramatic and exponentially increasing interest, in particular for their potential applications in the biomedical field. In this paper, we...

 Synonyms

MFCD00131218
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