Linderaspirone A

Modify Date: 2024-01-23 19:43:13

Linderaspirone A Structure
Linderaspirone A structure
Common Name Linderaspirone A
CAS Number 1235126-46-1 Molecular Weight 600.61
Density 1.3±0.1 g/cm3 Boiling Point 826.5±65.0 °C at 760 mmHg
Molecular Formula C34H32O10 Melting Point N/A
MSDS N/A Flash Point 340.9±34.3 °C

 Use of Linderaspirone A


Linderaspirone A is a natural compound that can be isolated from the roots of Lindera aggregate. Linderaspirone A shows significant inhibitory effects on the production of prostaglandin E2 (PGE2),TNF-α, and IL-6 [1][2].

 Names

Name (6E,8R,14E,16R)-2,3,6,11,12,14-Hexamethoxy-8,16-diphenyldispiro[4 .3.4.3]hexadeca-2,6,11,14-tetraene-1,4,10,13-tetrone
Synonym More Synonyms

 Linderaspirone A Biological Activity

Description Linderaspirone A is a natural compound that can be isolated from the roots of Lindera aggregate. Linderaspirone A shows significant inhibitory effects on the production of prostaglandin E2 (PGE2),TNF-α, and IL-6 [1][2].
Related Catalog
In Vitro Linderaspirone A also inhibits the expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2), which are pro-inflammatory proteins, and the activation of nuclear factor κB (NF-κB) [2].
References

[1]. Lin Chen, et al. Lindera cyclopentenedione intermediates from the roots of Lindera aggregate. RSC Adv. 2018 May 16;8(32):17898-17904.  

[2]. Chi-Su Yoon, et al. Effects of Compounds Isolated from Lindera erythrocarpa on Anti-Inflammatory and Anti-Neuroinflammatory Action in BV2 Microglia and RAW264.7 Macrophage. Int J Mol Sci. 2022 Jun 27;23(13):7122.  

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 826.5±65.0 °C at 760 mmHg
Molecular Formula C34H32O10
Molecular Weight 600.61
Flash Point 340.9±34.3 °C
Exact Mass 600.199524
PSA 123.66000
LogP 3.40
Vapour Pressure 0.0±3.0 mmHg at 25°C
Index of Refraction 1.615

 Safety Information

Hazard Codes Xi

 Synonyms

Dispiro[4.3.4.3]hexadeca-2,6,11,14-tetraene-1,4,10,13-tetrone, 2,3,6,11,12,14-hexamethoxy-8,16-diphenyl-, (6E,8R,14E,16R)-
(6E,8R,14E,16R)-2,3,6,11,12,14-Hexamethoxy-8,16-diphenyldispiro[4.3.4.3]hexadeca-2,6,11,14-tetraene-1,4,10,13-tetrone