PAR-4 Agonist Peptide, amide TFA
Modify Date: 2025-08-27 13:05:17
PAR-4 Agonist Peptide, amide TFA structure
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Common Name | PAR-4 Agonist Peptide, amide TFA | ||
|---|---|---|---|---|
| CAS Number | 1228078-65-6 | Molecular Weight | 794.82 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C36H49F3N8O9 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PAR-4 Agonist Peptide, amide TFAPAR-4 Agonist Peptide, amide TFA (PAR-4-AP TFA; AY-NH2 TFA) is a proteinase-activated receptor-4 (PAR-4) agonist, which has no effect on either PAR-1 or PAR-2 and whose effects are blocked by a PAR-4 antagonist[1]. |
| Name | PAR-4 Agonist Peptide, amide TFA |
|---|
| Description | PAR-4 Agonist Peptide, amide TFA (PAR-4-AP TFA; AY-NH2 TFA) is a proteinase-activated receptor-4 (PAR-4) agonist, which has no effect on either PAR-1 or PAR-2 and whose effects are blocked by a PAR-4 antagonist[1]. |
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| Related Catalog | |
| Target |
PAR-4[1] |
| In Vivo | Compared with their BALB/cBy controls, SCID mice have a significantly greater abdominal response to colorectal distension (CRD) at the distension levels of 0.04 to 0.1 mL increasing the intensity of EMG response by 384% to 132%, respectively (P<0.01; P<0.01; P<0.01; P<0.001). PAR-4 activation effectively reverses this hypersensitivity (P<0.01, P<0.05; P<0.05; P<0.05)[1]. |
| Animal Admin | Mice[1] SCID mice Male SCID mice and their BALB/cBy controls are operated as C57BL/6J mice, and on the 4th postoperative day mice receive intracolonically (IC) infusion of 100 μg PAR-4-AP or vehicle. Visceral pain measurements started 1 h following the end of infusion[1]. |
| References |
| Molecular Formula | C36H49F3N8O9 |
|---|---|
| Molecular Weight | 794.82 |
| InChIKey | BGPJLFVICWHITH-HKJXYENISA-N |
| SMILES | CC(N)C(=O)NC(Cc1ccc(O)cc1)C(=O)N1CCCC1C(=O)NCC(=O)NC(CCCCN)C(=O)NC(Cc1ccccc1)C(N)=O.O=C(O)C(F)(F)F |
| Storage condition | 2-8℃ |