PAR-4 Agonist Peptide, amide TFA
Names
[ CAS No. ]:
1228078-65-6
[ Name ]:
PAR-4 Agonist Peptide, amide TFA
Biological Activity
[Description]:
PAR-4 Agonist Peptide, amide TFA (PAR-4-AP TFA; AY-NH2 TFA) is a proteinase-activated receptor-4 (PAR-4) agonist, which has no effect on either PAR-1 or PAR-2 and whose effects are blocked by a PAR-4 antagonist[1].
[Related Catalog]:
[Target]
PAR-4[1]
[In Vivo]
Compared with their BALB/cBy controls, SCID mice have a significantly greater abdominal response to colorectal distension (CRD) at the distension levels of 0.04 to 0.1 mL increasing the intensity of EMG response by 384% to 132%, respectively (P<0.01; P<0.01; P<0.01; P<0.001). PAR-4 activation effectively reverses this hypersensitivity (P<0.01, P<0.05; P<0.05; P<0.05)[1].
[Animal admin]
Mice[1] SCID mice Male SCID mice and their BALB/cBy controls are operated as C57BL/6J mice, and on the 4th postoperative day mice receive intracolonically (IC) infusion of 100 μg PAR-4-AP or vehicle. Visceral pain measurements started 1 h following the end of infusion[1].
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C36H49F3N8O9
[ Molecular Weight ]:
794.82
[ Storage condition ]:
2-8℃