REACTIVE BLUE 2
REACTIVE BLUE 2 structure
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Common Name | REACTIVE BLUE 2 | ||
|---|---|---|---|---|
| CAS Number | 12236-82-7 | Molecular Weight | 774.15700 | |
| Density | 1.845 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C29H20ClN7O11S3 | Melting Point | >300ºC | |
| MSDS | N/A | Flash Point | N/A | |
Use of REACTIVE BLUE 2Procion Blue HB (Reactive Blue 2) is a purinergic antagonist. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | reactive blue 2 |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Procion Blue HB (Reactive Blue 2) is a purinergic antagonist. |
|---|---|
| Related Catalog | |
| In Vitro | Reactive Blue 2 is used as an ATP receptor antagonist and induces Ca2+ oscillations in HeLa cells. Reactive Blue 2 enhances a Ca2+ response to histamine that is linked to the PLC cascade. Reactive Blue 2 may activate the PLC cascade in an extracellular Ca2+-dependent manner and induce Ca2+ oscillations[1]. The application of Reactive Blue 2 increases K+ secretion in a dose-dependent manner, and this increase is characterized as a peak followed by a partial relaxation to a steady-state. Reactive Blue 2 has antagonistic activities at P2Y4, and the antagonist potency at P2Y4 paralleled the potency of K+ secretion[2].The anthraquinone dye reactive blue 2 is found to be a potent inhibitor of a protein kinase isolated and purified from thylakoids. The mode of inhibition is noncompetitive, with a Ki of 8 μM for the membrane-bound kinase, and 6 microM for the purified kinase. The inhibitor does not modify the substrate preference of the endogenous kinase and could be removed from the membrane by washing[3]. Reactive blue 2 selectively inhibits responses mediated via the P2ypurinoceptor, at least within a limited concentration range. In preparations where the tone has been raised with noradrenaline, ATP and 2-methylthio ATP, but not α,β-methylene ATP, produce relaxations of the vessel. These relaxations are inhibited in the presence of reactive blue 2[4]. Reactive blue 2, at concentrations of 0.3-10 μM blocks the ATP-induced oscillation in a concentration-dependent manner[5]. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.845 g/cm3 |
|---|---|
| Melting Point | >300ºC |
| Molecular Formula | C29H20ClN7O11S3 |
| Molecular Weight | 774.15700 |
| Exact Mass | 773.00700 |
| PSA | 323.17000 |
| LogP | 7.89610 |
| Index of Refraction | 1.777 |
| Storage condition | 2-8°C |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Water Solubility | H2O: soluble |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Hazard Codes | Xi: Irritant; |
|---|---|
| Risk Phrases | 36/37/38 |
| Safety Phrases | S24/25 |
| WGK Germany | 3 |
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| cibacron blue |
| Kayacion Blue A-B |
| BASILEN BLUE E-3G |
| C.I.REACTIVEBLUE2 |
| CIBRACONBLUEF3GA |
| PROCION BLUE HB |
| CIBACRON BLUE 3G-A |
| PROCION BLUE HBS |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the CAS number of reactive blue 2? |
| A: CAS number of reactive blue 2 is 12236-82-7. |
| Q: What is the safety information for reactive blue 2? |
| A: Safety information for reactive blue 2: S24/25. |
| Q: What are the uses of reactive blue 2? |
| A: Main uses of reactive blue 2: Procion Blue HB (Reactive Blue 2) is a purinergic antagonist. |
| Q: What is the melting point of reactive blue 2? |
| A: Melting point of reactive blue 2 is >300ºC. |
| Q: How is the water solubility of reactive blue 2? |
| A: Water solubility of reactive blue 2: H2O: soluble. |
| Q: What is the molecular formula of reactive blue 2? |
| A: Molecular formula of reactive blue 2 is C29H20ClN7O11S3. |
| Q: What are the storage conditions for reactive blue 2? |
| A: Storage conditions for reactive blue 2: 2-8°C. |
| Q: What is the polar surface area (PSA) of reactive blue 2? |
| A: Polar surface area (PSA) of reactive blue 2 is 323.17000. |
| Q: What is the LogP of reactive blue 2? |
| A: LogP of reactive blue 2 is 7.89610. |
| Q: What is the molecular weight of reactive blue 2? |
| A: Molecular weight of reactive blue 2 is 774.15700. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |