SAR629

Modify Date: 2025-08-24 23:34:11

SAR629 structure	Common Name	SAR629
	CAS Number	1221418-42-3	Molecular Weight	383.39
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₀H₁₉F₂N₅O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of SAR629

SAR629 is a potent monoglyceride lipase (MGL) covalent inhibitor. SAR629 also inhibits 2-Arachidonoylglycerol (2-AG) degradation[1][2].

Name	SAR629

Description	SAR629 is a potent monoglyceride lipase (MGL) covalent inhibitor. SAR629 also inhibits 2-Arachidonoylglycerol (2-AG) degradation[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
In Vitro	SAR629 is a potent dual inhibitory action on MAGL and fatty acid amide hydrolase (FAAH). SAR629 inhibits rodent monoglyceride lipase (MGL) activity at subnanomolar potencies (IC50 values of 1.1 nM and 219 pM in rat and mouse brain membranes, respectively)[1].
References	[1]. Niina Aaltonen, et al. Piperazine and piperidine triazole ureas as ultrapotent and highly selective inhibitors of monoacylglycerol lipase. Chem Biol. 2013 Mar 21;20(3):379-90. [2]. T Bertrand, et al. Structural basis for human monoglyceride lipase inhibition. J Mol Biol. 2010 Feb 26;396(3):663-73.

Molecular Formula	C₂₀H₁₉F₂N₅O
Molecular Weight	383.39

Hazard Codes	Xi

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: SAR629
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: SAR629
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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