4-Hydroxypropranolol D7 hydrochloride

Modify Date: 2024-01-06 09:27:17

4-Hydroxypropranolol D7 hydrochloride structure	Common Name	4-Hydroxypropranolol D7 hydrochloride
	CAS Number	1219804-03-1	Molecular Weight	282.386
	Density	1.2±0.1 g/cm3	Boiling Point	487.5±35.0 °C at 760 mmHg
	Molecular Formula	C₁₆H₁₅D₇ClNO₃	Melting Point	N/A
	MSDS	N/A	Flash Point	248.6±25.9 °C

Use of 4-Hydroxypropranolol D7 hydrochloride

4-Hydroxypropranolol D7 hydrochloride ((±)-4-hydroxy Propranolol D7 hydrochloride) is a deuterium labeled 4-Hydroxypropranolol hydrochloride. 4-Hydroxypropranolol hydrochlorid is an active metabolite of Propranolol, with potency comparable to Propranolol. 4-Hydroxypropranolol hydrochlorid inhibits β1- and β2-adrenergic receptors with pA2 values of 8.24 and 8.26, respectively. 4-Hydroxypropranolol hydrochlorid has intrinsic sympathomimetic activity, membrane stabilizing activity and potent antioxidant properties[1][2][3].

Name	4-[3-(1,1,1,2,3,3,3-heptadeuteriopropan-2-ylamino)-2-hydroxypropoxy]naphthalen-1-ol,hydrochloride
Synonym	More Synonyms

Description	4-Hydroxypropranolol D7 hydrochloride ((±)-4-hydroxy Propranolol D7 hydrochloride) is a deuterium labeled 4-Hydroxypropranolol hydrochloride. 4-Hydroxypropranolol hydrochlorid is an active metabolite of Propranolol, with potency comparable to Propranolol. 4-Hydroxypropranolol hydrochlorid inhibits β1- and β2-adrenergic receptors with pA2 values of 8.24 and 8.26, respectively. 4-Hydroxypropranolol hydrochlorid has intrinsic sympathomimetic activity, membrane stabilizing activity and potent antioxidant properties[1][2][3].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Neurological Disease
Target	pA2: 8.24 (β1-adrenergic receptor) and 8.26 (β2-adrenergic receptor)[2]
References	[1]. Fitzgerald JD, et al. Pharmacology of 4-hydroxypropranolol, a metabolite of propranolol. Br J Pharmacol. 1971 Sep;43(1):222-35. [2]. Nelson WL, et al. The 3,4-catechol derivative of propranolol, a minor dihydroxylated metabolite. J Med Chem. 1984 Jul;27(7):857-61. [3]. Ivan Tong Mak, et al. Potent Antioxidant Properties of 4-Hydroxyl-propranolol. Journal of Pharmacology and Experimental Therapeutics. 2004, 308(1):85-90.

Density	1.2±0.1 g/cm3
Boiling Point	487.5±35.0 °C at 760 mmHg
Molecular Formula	C₁₆H₁₅D₇ClNO₃
Molecular Weight	282.386
Flash Point	248.6±25.9 °C
Exact Mass	282.196075
PSA	61.72000
LogP	2.27
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.602

1-Naphthalenol, 4-[2-hydroxy-3-[[1-(methyl-d)ethyl-1,2,2,2-d]amino]propoxy]-

4-{2-Hydroxy-3-[(H)-2-propanylamino]propoxy}-1-naphthol

[2H7]-4-Hydroxypropranolol hydrochloride

4-Hydroxypropranolol D7 hydrochloride

Use of 4-Hydroxypropranolol D7 hydrochloride

Names

4-Hydroxypropranolol D7 hydrochloride Biological Activity

Chemical & Physical Properties

Synonyms