4-Hydroxypropranolol D7 hydrochloride

Names

[ CAS No. ]:
1219804-03-1

[ Name ]:
4-Hydroxypropranolol D7 hydrochloride

[Synonym ]:
1-Naphthalenol, 4-[2-hydroxy-3-[[1-(methyl-d)ethyl-1,2,2,2-d]amino]propoxy]-
4-{2-Hydroxy-3-[(H)-2-propanylamino]propoxy}-1-naphthol
[2H7]-4-Hydroxypropranolol hydrochloride

Biological Activity

[Description]:

4-Hydroxypropranolol D7 hydrochloride ((±)-4-hydroxy Propranolol D7 hydrochloride) is a deuterium labeled 4-Hydroxypropranolol hydrochloride. 4-Hydroxypropranolol hydrochlorid is an active metabolite of Propranolol, with potency comparable to Propranolol. 4-Hydroxypropranolol hydrochlorid inhibits β1- and β2-adrenergic receptors with pA2 values of 8.24 and 8.26, respectively. 4-Hydroxypropranolol hydrochlorid has intrinsic sympathomimetic activity, membrane stabilizing activity and potent antioxidant properties[1][2][3].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

Research Areas >> Neurological Disease

[Target]

pA2: 8.24 (β1-adrenergic receptor) and 8.26 (β2-adrenergic receptor)[2]

[References]

[1]. Fitzgerald JD, et al. Pharmacology of 4-hydroxypropranolol, a metabolite of propranolol. Br J Pharmacol. 1971 Sep;43(1):222-35.

[2]. Nelson WL, et al. The 3,4-catechol derivative of propranolol, a minor dihydroxylated metabolite. J Med Chem. 1984 Jul;27(7):857-61.

[3]. Ivan Tong Mak, et al. Potent Antioxidant Properties of 4-Hydroxyl-propranolol. Journal of Pharmacology and Experimental Therapeutics. 2004, 308(1):85-90.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
487.5±35.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₆H₁₅D₇ClNO₃

[ Molecular Weight ]:
282.386

[ Flash Point ]:
248.6±25.9 °C

[ Exact Mass ]:
282.196075

[ PSA ]:
61.72000

[ LogP ]:
2.27

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.602

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.