<Suppliers Price>

4-Hydroxypropranolol D7 hydrochloride

Names

[ CAS No. ]:
1219804-03-1

[ Name ]:
4-Hydroxypropranolol D7 hydrochloride

[Synonym ]:
1-Naphthalenol, 4-[2-hydroxy-3-[[1-(methyl-d)ethyl-1,2,2,2-d]amino]propoxy]-
4-{2-Hydroxy-3-[(H)-2-propanylamino]propoxy}-1-naphthol
[2H7]-4-Hydroxypropranolol hydrochloride

Biological Activity

[Description]:

4-Hydroxypropranolol D7 hydrochloride ((±)-4-hydroxy Propranolol D7 hydrochloride) is a deuterium labeled 4-Hydroxypropranolol hydrochloride. 4-Hydroxypropranolol hydrochlorid is an active metabolite of Propranolol, with potency comparable to Propranolol. 4-Hydroxypropranolol hydrochlorid inhibits β1- and β2-adrenergic receptors with pA2 values of 8.24 and 8.26, respectively. 4-Hydroxypropranolol hydrochlorid has intrinsic sympathomimetic activity, membrane stabilizing activity and potent antioxidant properties[1][2][3].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor
Research Areas >> Neurological Disease

[Target]

pA2: 8.24 (β1-adrenergic receptor) and 8.26 (β2-adrenergic receptor)[2]


[References]

[1]. Fitzgerald JD, et al. Pharmacology of 4-hydroxypropranolol, a metabolite of propranolol. Br J Pharmacol. 1971 Sep;43(1):222-35.

[2]. Nelson WL, et al. The 3,4-catechol derivative of propranolol, a minor dihydroxylated metabolite. J Med Chem. 1984 Jul;27(7):857-61.

[3]. Ivan Tong Mak, et al. Potent Antioxidant Properties of 4-Hydroxyl-propranolol. Journal of Pharmacology and Experimental Therapeutics. 2004, 308(1):85-90.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
487.5±35.0 °C at 760 mmHg

[ Molecular Formula ]:
C16H15D7ClNO3

[ Molecular Weight ]:
282.386

[ Flash Point ]:
248.6±25.9 °C

[ Exact Mass ]:
282.196075

[ PSA ]:
61.72000

[ LogP ]:
2.27

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.602

Related Compounds