Linalool-d3

Modify Date: 2024-01-18 07:42:46

Linalool-d3 Structure
Linalool-d3 structure
Common Name Linalool-d3
CAS Number 1216673-02-7 Molecular Weight 157.268
Density 0.9±0.1 g/cm3 Boiling Point 198.5±0.0 °C at 760 mmHg
Molecular Formula C10H15D3O Melting Point N/A
MSDS N/A Flash Point 76.1±0.0 °C

 Use of Linalool-d3


Linalool-d3 is the deuterium labeled Linalool[1]. Linalool is natural monoterpene in essential olis of coriander, acts as a competitive antagonist of Nmethyl d-aspartate (NMDA) receptor, with anti-tumor, anti-cardiotoxicity activity[2].Linalool is a PPARα ligand that reduces plasma TG levels and rewires the hepatic transcriptome and plasma metabolome[3].

 Names

Name Linalool(1,1,2-D3)
Synonym More Synonyms

 Linalool-d3 Biological Activity

Description Linalool-d3 is the deuterium labeled Linalool[1]. Linalool is natural monoterpene in essential olis of coriander, acts as a competitive antagonist of Nmethyl d-aspartate (NMDA) receptor, with anti-tumor, anti-cardiotoxicity activity[2].Linalool is a PPARα ligand that reduces plasma TG levels and rewires the hepatic transcriptome and plasma metabolome[3].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Oner Z1, et al. The protective and therapeutic effects of linalool against doxorubicin-induced cardiotoxicity in Wistar albino rats. Hum Exp Toxicol. 2019 Apr 12:960327119842634.  

[3]. Jun HJ, et al. Linalool is a PPARα ligand that reduces plasma TG levels and rewires the hepatic transcriptome and plasma metabolome. J Lipid Res. 2014 Jun55(6):1098-110.  

 Chemical & Physical Properties

Density 0.9±0.1 g/cm3
Boiling Point 198.5±0.0 °C at 760 mmHg
Molecular Formula C10H15D3O
Molecular Weight 157.268
Flash Point 76.1±0.0 °C
Exact Mass 157.154602
LogP 3.28
Vapour Pressure 0.1±0.8 mmHg at 25°C
Index of Refraction 1.463

 Synonyms

3,7-Dimethyl(1,1,2-H)-1,6-octadien-3-ol
Linalool(1,1,2-D3)
(±)-Linalool-d3 (vinyl-d3)
3,7-Dimethyl(1,1,2-H)octa-1,6-dien-3-ol
1,6-Octadien-1,1,2-d-3-ol, 3,7-dimethyl-