DDD 85646
Modify Date: 2025-08-24 20:59:39
DDD 85646 structure
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Common Name | DDD 85646 | ||
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| CAS Number | 1215010-55-1 | Molecular Weight | 495.425 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 684.3±65.0 °C at 760 mmHg | |
| Molecular Formula | 21H24Cl2N6O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 367.6±34.3 °C | |
Use of DDD 85646DDD 85646 is a potent, specific, dual N-Myristoyltransferase NMT1/NMT2 inhibitor with IC50 of 17 nM/22 nM respectively; inhibits myristoylation of an overexpressed protein construct in-cell-based microscopy assays; has no significant affect protein synthesis in cells; causes complete inhibition of N-myristoylation in cells at 1-10 uM; induces ER-stress, cell cycle arrest, and apoptosis in cancer cells. |
| Name | 2,6-Dichloro-4-(2-Piperazin-1-Ylpyridin-4-Yl)-N-(1,3,5-Trimethyl-1h-Pyrazol-4-Yl)benzenesulfonamide |
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| Synonym | More Synonyms |
| Description | DDD 85646 is a potent, specific, dual N-Myristoyltransferase NMT1/NMT2 inhibitor with IC50 of 17 nM/22 nM respectively; inhibits myristoylation of an overexpressed protein construct in-cell-based microscopy assays; has no significant affect protein synthesis in cells; causes complete inhibition of N-myristoylation in cells at 1-10 uM; induces ER-stress, cell cycle arrest, and apoptosis in cancer cells. |
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| References | References 1. Thinon E, et al. Nat Commun. 2014 Sep 26;5:4919. 2. Thinon E, et al. ACS Chem Biol. 2016 Aug 19;11(8):2165-76. 3. Brand S, et al. J Med Chem. 2012 Jan 12;55(1):140-52. View Related Products by Target Other Targets |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 684.3±65.0 °C at 760 mmHg |
| Molecular Formula | 21H24Cl2N6O2S |
| Molecular Weight | 495.425 |
| Flash Point | 367.6±34.3 °C |
| Exact Mass | 494.105835 |
| LogP | 2.28 |
| Vapour Pressure | 0.0±2.1 mmHg at 25°C |
| Index of Refraction | 1.693 |
| InChIKey | XMBSZPZJLPTFMV-UHFFFAOYSA-N |
| SMILES | Cc1nn(C)c(C)c1NS(=O)(=O)c1c(Cl)cc(-c2ccnc(N3CCNCC3)c2)cc1Cl |
| DDD85646; 2,6-dichloro-4-(2-piperazin-1-ylpyridin-4-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)-benzenesulfonamide |
| 2,6-Dichloro-4-(2-(piperazin-1-yl)pyridin-4-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide |
| Benzenesulfonamide, 2,6-dichloro-4-[2-(1-piperazinyl)-4-pyridinyl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)- |
| 2,6-Dichloro-4-(2-Piperazin-1-Ylpyridin-4-Yl)-N-(1,3,5-Trimethyl-1h-Pyrazol-4-Yl)benzenesulfonamide |
| 2,6-Dichloro-4-[2-(1-piperazinyl)-4-pyridinyl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide |